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General Medication Fact Sheet for Granisetron
| Field | Information |
|---|---|
| Generic Name | Granisetron |
| Brand Name Versions | Kytril, Sancuso |
| Purpose | Prevention of nausea and vomiting caused by chemotherapy or radiation therapy. |
| Mechanism of Action | Selective 5-HT3 receptor antagonist, blocking serotonin’s action in the vomiting center of the brain. |
| Dosage Forms | Oral tablets, intravenous solution, transdermal patch |
| Available Strengths | 1 mg, 2 mg (tablets); 1 mg/mL (IV solution); 3.1 mg/24 hours, 5.2 mg/24 hours (patch) |
| Dosage Frequency | Varies depending on the form and treatment regimen. Typically once daily or as directed by a healthcare provider. |
| Common Side Effects | Headache, constipation, diarrhea, weakness |
| Serious Side Effects | Serotonin syndrome (agitation, hallucinations, rapid heart rate, fever), allergic reactions (rash, itching, swelling, difficulty breathing), abnormal heart rhythm (QT prolongation) |
| Drug Interactions | Other drugs that affect serotonin levels (e.g., SSRIs, SNRIs), drugs that prolong the QT interval (e.g., antiarrhythmics, certain antibiotics) |
| Important Notes | Inform your doctor of all medications you are taking. Monitor for signs of allergic reactions or serotonin syndrome. |
| Storage | Store tablets at room temperature away from moisture and light. Store IV solution as directed. Store transdermal patch as directed. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose. |
| Alternatives | Ondansetron, Palonosetron, Metoclopramide, Prochlorperazine |
Granisetron Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ondansetron (Zofran) | Selective 5-HT3 receptor antagonist | Commonly used to prevent nausea and vomiting. |
| Palonosetron (Aloxi) | Selective 5-HT3 receptor antagonist with a longer half-life | May be more effective for delayed nausea and vomiting. |
| Metoclopramide (Reglan) | Dopamine antagonist and 5-HT4 receptor agonist | Can increase gastrointestinal motility. |
| Prochlorperazine (Compazine) | Dopamine antagonist | Also has antiemetic properties. |
Granisetron Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Serotonin syndrome (agitation, hallucinations, rapid heart rate, fever) |
| Constipation | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Abnormal heart rhythm (QT prolongation) |
| Weakness |
Granisetron Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chemotherapy-Induced Nausea/Vomiting (Oral) | 1 mg | 1 mg once daily or 2 mg once daily | Administer 1 hour before chemotherapy. |
| Chemotherapy-Induced Nausea/Vomiting (IV) | 10 mcg/kg | Single dose | Administer slowly over 5 minutes, 30 minutes before chemotherapy. |
| Radiation-Induced Nausea/Vomiting (Oral) | 2 mg | 2 mg once daily | Administer 1 hour before radiation. |
Granisetron Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $75 |
| From CPS | $15 |
