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Hepsera (Adefovir Dipivoxil)
| Adefovir Dipivoxil (Generic) Adefovir Dipivoxil | ||||||
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General Medication Fact Sheet for Hepsera
| Field | Information |
|---|---|
| Medication Name | Hepsera |
| Generic Name | Adefovir Dipivoxil |
| Boxed/Label Warning | Possible exacerbation of hepatitis upon discontinuation; risk of nephrotoxicity and lactic acidosis/hepatomegaly with steatosis. |
| Purpose | Antiviral medication used to treat chronic hepatitis B virus (HBV) infection. |
| Mechanism of Action | Inhibits HBV DNA polymerase by competing with natural substrates, thus blocking viral replication. |
| Dosage Forms | Oral tablets |
| Available Strengths | 10 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Weakness, headache, abdominal pain, nausea. |
| Serious Side Effects | Kidney problems, lactic acidosis, liver problems (hepatomegaly with steatosis), exacerbation of hepatitis B upon discontinuation. |
| Drug Interactions | Drugs affecting kidney function (e.g., aminoglycosides, NSAIDs), tenofovir, lamivudine, Entecavir. |
| Important Notes | Regular monitoring of kidney function is essential. Do not discontinue abruptly without medical advice due to risk of hepatitis flare. This medication does not cure hepatitis B but helps to control the virus. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Entecavir (Baraclude), Tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide (Vemlidy), Lamivudine (Epivir HBV) |
Hepsera Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Entecavir (Baraclude) | Inhibits HBV DNA polymerase. | Generally preferred first-line treatment due to higher barrier to resistance. |
| Tenofovir disoproxil fumarate (Viread) | Inhibits HBV DNA polymerase. | Effective antiviral with a good resistance profile. |
| Tenofovir alafenamide (Vemlidy) | Inhibits HBV DNA polymerase. | Newer formulation of tenofovir with potentially fewer kidney and bone side effects. |
| Lamivudine (Epivir HBV) | Inhibits HBV DNA polymerase. | Higher risk of resistance compared to Entecavir and tenofovir; often used in combination therapy or when other options are not suitable. |
Hepsera Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Weakness | Kidney problems |
| Headache | Lactic acidosis |
| Abdominal pain | Liver problems (hepatomegaly with steatosis) |
| Nausea | Exacerbation of hepatitis B upon discontinuation |
| Diarrhea | Muscle weakness or pain |
Hepsera Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Hepatitis B | 10 mg | 10 mg once daily | Take orally, with or without food. Regular kidney function monitoring is required. |
Hepsera Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $35 |
| Without Insurance (U.S.) | $150 |
| From CPS | $120 |
