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General Medication Fact Sheet for Hulio
| Field | Information |
|---|---|
| Medication Name | Hulio |
| Generic Name | Adalimumab-adaz |
| Boxed/Label Warning | Serious Infections and Malignancy |
| Purpose | Biosimilar to Humira (adalimumab) used to treat autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, and hidradenitis suppurativa. |
| Mechanism of Action | A tumor necrosis factor (TNF) blocker that works by blocking the activity of TNF, a substance in the body that can cause inflammation. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 40 mg/0.8 mL |
| Dosage Frequency | Varies depending on the condition being treated; typically every 1-2 weeks. |
| Common Side Effects | Injection site reactions (pain, swelling, redness, itching), upper respiratory infections (sinus infections, sore throat), headache, rash. |
| Serious Side Effects | Serious infections (tuberculosis, fungal infections, bacterial infections), lymphoma and other cancers, nervous system problems (multiple sclerosis, seizures, optic neuritis), liver problems, heart failure, allergic reactions. |
| Drug Interactions | Other TNF blockers, anakinra, abatacept, live vaccines, immunosuppressants (azathioprine, cyclosporine). |
| Important Notes | Increased risk of infections. Patients should be evaluated for TB risk prior to starting therapy. Consult a healthcare provider before receiving live vaccines. |
| Storage | Store in the refrigerator at 2-8°C (36-46°F). Do not freeze. Protect from light. |
| Missed Dose | Inject the missed dose as soon as you remember. Then, take your next dose at your regular scheduled time. |
| Alternatives | Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab), Cimzia (certolizumab pegol), Stelara (ustekinumab). |
Hulio Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Humira (adalimumab) | TNF-alpha inhibitor | The originator biologic of Hulio. |
| Enbrel (etanercept) | TNF-alpha inhibitor | Another TNF inhibitor used for similar indications. |
| Remicade (infliximab) | TNF-alpha inhibitor | Administered via intravenous infusion. |
| Cimzia (certolizumab pegol) | TNF-alpha inhibitor | Another TNF inhibitor with a different formulation. |
| Stelara (ustekinumab) | IL-12 and IL-23 inhibitor | Works through a different mechanism to reduce inflammation. |
Hulio Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (pain, swelling, redness, itching) | Serious infections (tuberculosis, fungal infections, bacterial infections) |
| Upper respiratory infections (sinus infections, sore throat) | Lymphoma and other cancers |
| Headache | Nervous system problems (multiple sclerosis, seizures, optic neuritis) |
| Rash | Liver problems |
| Nausea | Heart failure |
| Back Pain | Allergic reactions (hives, difficulty breathing, swelling of the face, lips, tongue, or throat) |
Hulio Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 40 mg every other week | 40 mg every other week | May be given weekly if not on methotrexate. Subcutaneous injection. |
| Psoriatic Arthritis | 40 mg every other week | 40 mg every other week | Subcutaneous injection. |
| Ankylosing Spondylitis | 40 mg every other week | 40 mg every other week | Subcutaneous injection. |
| Crohn’s Disease (Adults) | 160 mg initially (Day 1), then 80 mg at week 2, followed by 40 mg every other week starting at week 4 | 40 mg every other week | Subcutaneous injection. Loading dose required. |
| Ulcerative Colitis (Adults) | 160 mg initially (Day 1), then 80 mg at week 2, followed by 40 mg every other week starting at week 4 | 40 mg every other week | Subcutaneous injection. Loading dose required. |
| Plaque Psoriasis | 80 mg initially, then 40 mg every other week starting one week after the initial dose | 40 mg every other week | Subcutaneous injection. |
| Hidradenitis Suppurativa | 160 mg initially (Day 1), then 80 mg at week 2, followed by 40 mg every week or 40 mg every other week starting at week 4. | 40 mg weekly or 40 mg every other week | Subcutaneous injection. |
Hulio Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $5,500 |
| Without Insurance (U.S.) | $7,000 |
| From CPS | $742 |
