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Humira (Adalimumab)
General Medication Fact Sheet for Humira
| Field | Information |
|---|---|
| Medication Name | Humira |
| Generic Name | Adalimumab |
| Boxed/Label Warning | Serious infections and malignancies. See prescribing information for full details. |
| Purpose | Treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis. |
| Mechanism of Action | Tumor necrosis factor (TNF) blocker; binds to TNF-alpha, preventing it from activating TNF receptors. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 40 mg/0.8 mL, 40 mg/0.4 mL, 80 mg/0.8 mL |
| Dosage Frequency | Every other week or weekly, depending on the condition being treated. |
| Common Side Effects | Injection site reactions (pain, swelling, redness, itching), upper respiratory infections, headache, rash. |
| Serious Side Effects | Serious infections (e.g., tuberculosis, fungal infections), lymphoma and other cancers, heart failure, nervous system disorders, liver problems, blood disorders, allergic reactions. |
| Drug Interactions | Other TNF blockers (e.g., etanercept, infliximab), anakinra, abatacept, live vaccines, methotrexate, azathioprine. |
| Important Notes | Patients should be screened for tuberculosis before starting Humira and monitored for infections during treatment. Humira can increase the risk of certain cancers. |
| Storage | Store in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze. Keep in the original carton to protect from light. If needed, Humira can be stored at room temperature up to 77°F (25°C) for a maximum of 14 days, but then it must be discarded. |
| Missed Dose | Inject the missed dose as soon as you remember, then continue with your regular schedule. |
| Alternatives | Enbrel (etanercept), Remicade (infliximab), Cimzia (certolizumab pegol), Stelara (ustekinumab) |
Humira Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Enbrel (etanercept) | TNF blocker | Another TNF inhibitor, similar to Humira. Used for rheumatoid arthritis, psoriatic arthritis, and other inflammatory conditions. |
| Remicade (infliximab) | TNF blocker | Administered via intravenous infusion. Used for rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. |
| Cimzia (certolizumab pegol) | TNF blocker | Another TNF inhibitor with a different structure. |
| Stelara (ustekinumab) | IL-12 and IL-23 inhibitor | Works by blocking interleukin-12 and interleukin-23. Used for plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. |
Humira Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (pain, swelling, redness, itching) | Serious infections (e.g., tuberculosis, fungal infections, sepsis) |
| Upper respiratory infections (sinus infections, colds) | Lymphoma and other cancers |
| Headache | Heart failure |
| Rash | Nervous system disorders (e.g., multiple sclerosis-like symptoms, seizures) |
| Nausea | Liver problems |
| Abdominal pain | Blood disorders (e.g., anemia, leukopenia, thrombocytopenia) |
| Back pain | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Humira Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 40 mg every other week | 40 mg every other week, may increase to 40 mg weekly | Administered as a subcutaneous injection. May be used alone or with methotrexate. |
| Psoriatic Arthritis | 40 mg every other week | 40 mg every other week | Administered as a subcutaneous injection. |
| Ankylosing Spondylitis | 40 mg every other week | 40 mg every other week | Administered as a subcutaneous injection. |
| Crohn’s Disease | 160 mg at week 0, 80 mg at week 2 | 40 mg every other week | Administered as subcutaneous injections. |
| Ulcerative Colitis | 160 mg at week 0, 80 mg at week 2 | 40 mg every other week | Administered as subcutaneous injections. |
| Plaque Psoriasis | 80 mg initial dose, then 40 mg every other week starting one week after the initial dose. | 40 mg every other week | Administered as a subcutaneous injection. |
Humira Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $500 |
| Without Insurance (U.S.) | $7000 |
| From Canada | $5500 |
