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General Medication Fact Sheet for Hydralazine
| Field | Information |
|---|---|
| Generic Name | Hydralazine |
| Brand Name Versions | Apresoline |
| Boxed/Label Warning | Hydralazine may produce a lupus erythematosus-like syndrome. |
| Purpose | Antihypertensive used to treat high blood pressure |
| Mechanism of Action | Directly relaxes arteriolar smooth muscle, causing vasodilation |
| Dosage Forms | Oral tablets, Injection |
| Available Strengths | 10 mg, 25 mg, 50 mg, 100 mg |
| Dosage Frequency | Typically two to four times daily, or as directed by a healthcare provider |
| Common Side Effects | Headache, palpitations, flushing, nausea, dizziness |
| Serious Side Effects | Lupus-like syndrome, severe hypotension, tachycardia, peripheral neuritis |
| Drug Interactions | Other antihypertensives, MAO inhibitors, NSAIDs |
| Important Notes | Monitor blood pressure regularly; report any signs of lupus-like syndrome (joint pain, fever, rash) to your doctor |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Lisinopril, Amlodipine, Metoprolol, Losartan |
Hydralazine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lisinopril | ACE inhibitor, prevents the production of angiotensin II, leading to vasodilation. | Commonly used first-line treatment for hypertension. |
| Amlodipine | Calcium channel blocker, relaxes blood vessels by preventing calcium from entering smooth muscle cells. | Effective for lowering blood pressure; can cause swelling in ankles. |
| Metoprolol | Beta-blocker, blocks the effects of adrenaline, slowing the heart rate and reducing blood pressure. | Also used for angina and heart failure. |
| Losartan | Angiotensin II receptor blocker (ARB), blocks the action of angiotensin II, resulting in vasodilation. | Alternative to ACE inhibitors with similar effects. |
Hydralazine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Lupus-like syndrome (joint pain, fever, rash) |
| Palpitations | Severe hypotension |
| Flushing | Tachycardia |
| Nausea | Peripheral neuritis (numbness, tingling in hands or feet) |
| Dizziness | Severe allergic reaction |
Hydralazine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Hypertension | 10 mg | 25-50 mg two to four times daily | Adjust dosage based on blood pressure response. |
| Hypertensive Emergency (IV) | 10-20 mg | Repeat as needed, or switch to oral therapy. | Administer slowly, monitoring blood pressure closely. |
Hydralazine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $25 |
| From Canada | $15 |
