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General Medication Fact Sheet for Ivabradine
| Field | Information |
|---|---|
| Generic Name | Ivabradine |
| Brand Name Versions | Corlanor |
| Purpose | Used to treat heart failure and stable angina (chest pain). |
| Mechanism of Action | Selectively inhibits the If current in the sinoatrial (SA) node, slowing the heart rate. |
| Dosage Forms | Oral tablets |
| Available Strengths | 2.5 mg, 5 mg, 7.5 mg |
| Dosage Frequency | Typically twice daily, with meals. |
| Common Side Effects | Bradycardia (slow heart rate), visual disturbances (phosphenes), headache, dizziness. |
| Serious Side Effects | Atrial fibrillation, severe bradycardia, heart block. |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), CYP3A4 inducers (e.g., rifampin), other heart rate lowering medications (e.g., beta-blockers, digoxin). |
| Important Notes | Inform your doctor of all medications and supplements you are taking. Regular monitoring of heart rate and rhythm is recommended. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Beta-blockers, Calcium Channel Blockers, Nitrates. |
Ivabradine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metoprolol (Lopressor, Toprol XL) | Beta-blocker; blocks the effects of adrenaline, slowing heart rate and lowering blood pressure. | Commonly used for angina and heart failure. |
| Amlodipine (Norvasc) | Calcium channel blocker; relaxes blood vessels, improving blood flow and reducing blood pressure. | Used for angina and hypertension. |
| Nitroglycerin (Nitrostat) | Vasodilator; widens blood vessels, increasing blood flow to the heart. | Used to relieve angina symptoms. |
Ivabradine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Bradycardia (slow heart rate) | Atrial fibrillation |
| Visual disturbances (phosphenes – brief enhanced brightness) | Severe bradycardia |
| Headache | Heart block |
| Dizziness | Worsening of heart failure |
Ivabradine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Stable Angina | 5 mg twice daily | Adjusted based on heart rate, up to 7.5 mg twice daily. | Take with food. |
| Heart Failure | 5 mg twice daily | Adjusted based on heart rate and tolerance. | Take with food. |
Ivabradine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 – $50 |
| Without Insurance (U.S.) | $300 – $500 |
| From Canada | $50 – $100 |
