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Janumet (Metformin & Sitagliptin)
| Apo-Sitagliptin/Metformin XR (Generic) Sitagliptin, Metformin | ||||||
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Shipped from Canada | ||||||
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| Auro-Sitagliptin/Metformin (Generic) Sitagliptin, Metformin | ||||||
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Shipped from Canada | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Janumet
| Field | Information |
|---|---|
| Medication Name | Janumet |
| Generic Name | Metformin/Sitagliptin |
| Boxed/Label Warning | Lactic acidosis, a serious metabolic complication, can occur due to metformin accumulation. |
| Purpose | Used to treat type 2 diabetes mellitus by helping to control blood sugar levels |
| Mechanism of Action | Metformin decreases glucose production in the liver and increases insulin sensitivity. Sitagliptin enhances incretin hormones, increasing insulin release and decreasing glucagon secretion. |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg/500 mg, 50 mg/850 mg, 50 mg/1000 mg (Sitagliptin/Metformin) |
| Dosage Frequency | Typically twice daily, taken with meals, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, diarrhea, stomach upset, headache |
| Serious Side Effects | Lactic acidosis, pancreatitis, kidney problems, heart failure, severe joint pain |
| Drug Interactions | Insulin, sulfonylureas, diuretics, corticosteroids, thyroid medications, certain antibiotics (e.g., cimetidine), alcohol |
| Important Notes | Take with food to minimize stomach upset; regular kidney function monitoring is recommended; avoid excessive alcohol consumption. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Metformin, Sitagliptin (Januvia), Glipizide, Empagliflozin (Jardiance), Semaglutide (Ozempic) |
Janumet Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metformin | Decreases glucose production in the liver and increases insulin sensitivity. | A common first-line treatment for type 2 diabetes. |
| Sitagliptin (Januvia) | Enhances incretin hormones, increasing insulin release and decreasing glucagon secretion. | A DPP-4 inhibitor often used in combination with metformin. |
| Glipizide | Stimulates insulin release from the pancreas. | A sulfonylurea that can be used to lower blood sugar. |
| Empagliflozin (Jardiance) | Inhibits SGLT2 in the kidneys, increasing glucose excretion in the urine. | An SGLT2 inhibitor with cardiovascular benefits. |
| Semaglutide (Ozempic) | GLP-1 receptor agonist that enhances insulin secretion and suppresses glucagon secretion. | Injectable medication also available in oral form (Rybelsus). |
Janumet Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Lactic acidosis (muscle pain, fatigue, difficulty breathing) |
| Vomiting | Pancreatitis (severe abdominal pain, nausea, vomiting) |
| Diarrhea | Kidney problems (decreased urination, swelling) |
| Stomach upset | Heart failure (shortness of breath, swelling ankles/feet) |
| Headache | Severe joint pain |
Janumet Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Type 2 Diabetes | 50 mg/500 mg twice daily | Adjusted based on individual response, up to a maximum of 100 mg/2000 mg daily. | Take with meals to reduce gastrointestinal side effects. |
