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Lantus (Insulin Glargine)
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| Lantus Vial Insulin Glargine | ||||||
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General Medication Fact Sheet for Lantus
| Field | Information |
|---|---|
| Medication Name | Lantus |
| Generic Name | Insulin glargine |
| Purpose | Long-acting insulin used to control high blood sugar in adults and children with diabetes mellitus |
| Mechanism of Action | Replaces or supplements the body’s own insulin to help glucose enter cells, lowering blood sugar levels |
| Dosage Forms | Solution for subcutaneous injection |
| Available Strengths | 100 units/mL (U-100) |
| Dosage Frequency | Once daily, at the same time each day |
| Common Side Effects | Low blood sugar (hypoglycemia), injection site reactions (redness, swelling, itching), weight gain |
| Serious Side Effects | Severe hypoglycemia, allergic reactions (rash, itching, swelling, difficulty breathing), hypokalemia (low potassium) |
| Drug Interactions | Other diabetes medications (e.g., oral antidiabetics, rapid-acting insulin), beta-blockers, ACE inhibitors, alcohol, corticosteroids |
| Important Notes | Do not share insulin pens or syringes. Monitor blood sugar regularly. Rotate injection sites. |
| Storage | Unopened vials/pens: Store in the refrigerator (36°F – 46°F) until the expiration date. Opened vials/pens: Store at room temperature (below 86°F) and use within 28 days. Do not freeze. |
| Missed Dose | Take the missed dose as soon as you remember, but do not double the dose to catch up. |
| Alternatives | Tresiba, Levemir, Basaglar (insulin glargine), Toujeo |
Lantus Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tresiba (insulin degludec) | Long-acting insulin analogue | Ultra-long duration of action (up to 42 hours), providing stable basal coverage. |
| Levemir (insulin detemir) | Long-acting insulin analogue | Provides basal insulin coverage, duration of action may vary depending on the dose. |
| Basaglar (insulin glargine) | Long-acting insulin analogue | Biosimilar to Lantus, provides similar basal insulin coverage. |
| Toujeo (insulin glargine U-300) | Long-acting insulin analogue | Concentrated form of insulin glargine, providing a more stable and prolonged release. |
Lantus Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Low blood sugar (hypoglycemia) | Severe hypoglycemia (can lead to unconsciousness or seizures) |
| Injection site reactions (redness, swelling, itching) | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Weight gain | Hypokalemia (low potassium levels) |
| Skin thickening or pitting at injection site (lipodystrophy) | Vision changes |
| Edema (swelling in extremities) | Heart failure (rare) |
Lantus Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Type 1 Diabetes | Individualized, typically 0.2-0.4 units/kg/day | Individualized, based on blood glucose monitoring | Administer subcutaneously once daily, at the same time each day. Rotate injection sites. |
| Type 2 Diabetes | Individualized, typically 10 units once daily or 0.1-0.2 units/kg/day | Individualized, based on blood glucose monitoring | Administer subcutaneously once daily, at the same time each day. May be used with oral antidiabetic medications. Rotate injection sites. |


