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General Medication Fact Sheet for Leqvio
| Field | Information |
|---|---|
| Medication Name | Leqvio |
| Generic Name | Inclisiran |
| Purpose | Lowers LDL-C (bad cholesterol) in adults with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia, as an adjunct to diet and statin therapy. |
| Mechanism of Action | Inhibits the synthesis of PCSK9 (proprotein convertase subtilisin/kexin type 9) in the liver, which increases the liver’s ability to remove LDL-C from the blood. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 284 mg/1.5 mL |
| Dosage Frequency | Initial dose, then a second dose 3 months later, followed by doses every 6 months. |
| Common Side Effects | Injection site reactions (pain, redness, swelling), joint pain, urinary tract infection, diarrhea, chest cold (bronchitis), shortness of breath, and pain in the arms or legs |
| Serious Side Effects | Allergic reactions (rash, itching, swelling, dizziness, trouble breathing). |
| Drug Interactions | No significant drug interactions have been identified, but inform your healthcare provider of all medications you are taking. |
| Important Notes | Leqvio should be used in conjunction with a cholesterol-lowering diet and statin therapy, unless statins are contraindicated. |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze. If necessary, Leqvio can be stored at room temperature up to 25°C (77°F) for no more than 60 days. |
| Missed Dose | Contact your healthcare provider for instructions on rescheduling your injection. Do not double the dose. |
| Alternatives | Atorvastatin (Lipitor), Rosuvastatin (Crestor), Ezetimibe (Zetia), Praluent (alirocumab), Repatha (evolocumab) |
Leqvio Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Atorvastatin (Lipitor) | HMG-CoA reductase inhibitor (statin) | Reduces cholesterol production in the liver. |
| Rosuvastatin (Crestor) | HMG-CoA reductase inhibitor (statin) | More potent than some other statins. |
| Ezetimibe (Zetia) | Cholesterol absorption inhibitor | Reduces cholesterol absorption in the small intestine. |
| Praluent (alirocumab) | PCSK9 inhibitor | Monoclonal antibody that inhibits PCSK9, similar to Leqvio but requires more frequent injections. |
| Repatha (evolocumab) | PCSK9 inhibitor | Monoclonal antibody that inhibits PCSK9, similar to Leqvio but requires more frequent injections. |
Leqvio Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (pain, redness, swelling) | Allergic reactions (rash, itching, swelling) |
| Joint pain | Severe allergic reactions (difficulty breathing, dizziness) |
| Urinary tract infection | |
| Diarrhea | |
| Bronchitis | |
| Shortness of breath | |
| Pain in the arms or legs |
Leqvio Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Atherosclerotic Cardiovascular Disease | 284 mg | 284 mg every 6 months after initial and 3-month doses. | Subcutaneous injection. Administered by a healthcare professional. |
| Heterozygous Familial Hypercholesterolemia | 284 mg | 284 mg every 6 months after initial and 3-month doses. | Subcutaneous injection. Administered by a healthcare professional. |
Leqvio Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $75 |
| Without Insurance (U.S.) | $3200 |
| From Canada | $3000 |
