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General Medication Fact Sheet for Linzess
| Field | Information |
|---|---|
| Medication Name | Linzess |
| Generic Name | Linaclotide |
| Purpose | Used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) |
| Mechanism of Action | Guanylate cyclase-C (GC-C) agonist that increases intestinal fluid secretion and accelerates gastrointestinal transit |
| Dosage Forms | Oral capsules |
| Available Strengths | 72 mcg, 145 mcg, 290 mcg |
| Dosage Frequency | Once daily |
| Common Side Effects | Diarrhea, abdominal pain, gas, bloating |
| Serious Side Effects | Severe diarrhea, dehydration, rectal bleeding |
| Drug Interactions | There are no significant known drug interactions with Linzess, but consult your doctor about all medications you take |
| Important Notes | Take on an empty stomach, at least 30 minutes before a meal; avoid if you have a bowel blockage |
| Storage | Store at room temperature away from moisture and heat; keep capsules in original container |
| Missed Dose | Skip the missed dose and take the next dose at the regular time; do not double the dose |
| Alternatives | Amitiza, Trulance, Lactulose, Polyethylene Glycol 3350 (Miralax) |
Linzess Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Amitiza (lubiprostone) | Chloride channel activator that increases fluid secretion in the intestine | Available for IBS-C and CIC. |
| Trulance (plecanatide) | Guanylate cyclase-C (GC-C) agonist, similar to Linzess | Also increases fluid secretion and promotes bowel movements. |
| Lactulose | Osmotic laxative that draws water into the colon | Available as a generic liquid. |
| Polyethylene Glycol 3350 (Miralax) | Osmotic laxative that draws water into the colon | Available over-the-counter. |
Linzess Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Severe diarrhea |
| Abdominal pain | Dehydration |
| Gas | Rectal bleeding |
Linzess Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Irritable Bowel Syndrome with Constipation (IBS-C) | 145 mcg | 145 mcg once daily | Take on an empty stomach, 30 minutes before a meal. |
| Chronic Idiopathic Constipation (CIC) | 72 mcg | 72 mcg, 145 mcg, or 290 mcg once daily (depending on response and tolerability) | Take on an empty stomach, 30 minutes before a meal. |
Linzess Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $35 |
| Without Insurance (U.S.) | $400 |
| From Canada | $300 |

