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Lioresal (Baclofen)
| Baclofen (Generic) Baclofen | ||||||
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Shipped from Canada | ||||||
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| Baclofen (Generic) Baclofen | ||||||
Shipped from United Kingdom | ||||||
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| Liofen (Generic) Baclofen | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Lioresal
| Field | Information |
|---|---|
| Medication Name | Lioresal |
| Generic Name | Baclofen |
| Boxed/Label Warning | Abrupt withdrawal of Lioresal, especially in patients with intrathecal administration, has resulted in serious adverse effects, including high fever, altered mental status, muscle rigidity, and in rare cases, death. |
| Purpose | Muscle relaxant and antispastic agent used to treat muscle spasms caused by conditions such as multiple sclerosis, spinal cord injuries, or other nervous system disorders. |
| Mechanism of Action | Baclofen acts as a GABA-B receptor agonist, inhibiting nerve signals in the spinal cord that cause muscle spasticity. |
| Dosage Forms | Oral tablets, Intrathecal solution |
| Available Strengths | 10 mg, 20 mg tablets; 0.05 mg/mL, 0.5 mg/mL, 2 mg/mL intrathecal solutions |
| Dosage Frequency | Typically three times daily, or as directed by a healthcare provider. Intrathecal administration frequency varies. |
| Common Side Effects | Drowsiness, dizziness, weakness, fatigue, headache, nausea, confusion, insomnia, hypotension |
| Serious Side Effects | Seizures, hallucinations, respiratory depression, severe muscle weakness, urinary retention, withdrawal symptoms (especially with abrupt discontinuation) |
| Drug Interactions | Alcohol, other CNS depressants (e.g., benzodiazepines, opioids), tricyclic antidepressants, antihypertensive medications |
| Important Notes | Avoid alcohol and other CNS depressants while taking this medication. Do not stop taking Lioresal abruptly, as withdrawal symptoms can occur. Use caution when driving or operating machinery until you know how this medication affects you. |
| Storage | Store at room temperature away from moisture and light. Intrathecal solution should be stored according to manufacturer instructions. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Tizanidine, Diazepam, Dantrolene, Cyclobenzaprine |
Lioresal Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tizanidine (Zanaflex) | Alpha-2 adrenergic agonist | Another muscle relaxant; may cause drowsiness and hypotension. |
| Diazepam (Valium) | Benzodiazepine; GABA-A receptor agonist | Has muscle relaxant and anti-anxiety effects; potential for dependence. |
| Dantrolene (Dantrium) | Ryanodine receptor antagonist | Acts directly on skeletal muscle to reduce spasms; can cause liver problems. |
| Cyclobenzaprine (Flexeril) | Central muscle relaxant | Effective for acute muscle spasms; can cause drowsiness and dry mouth. |
Lioresal Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Seizures |
| Dizziness | Hallucinations |
| Weakness | Respiratory depression |
| Fatigue | Severe muscle weakness |
| Headache | Urinary retention |
| Nausea | Withdrawal symptoms (especially with abrupt discontinuation) |
| Confusion | Hypotension |
Lioresal Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Muscle Spasticity (Oral) | 5 mg three times daily | Gradually increase by 5 mg every three days until desired effect is achieved (max 80 mg/day). | Take with food if stomach upset occurs. |
| Muscle Spasticity (Intrathecal) | Initial test dose of 50 mcg | Adjusted based on response (typical maintenance dose is 300-800 mcg/day). | Administered via intrathecal pump directly into the spinal fluid. |
Lioresal Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $80 |
| From Canada | $30 |
