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Lixiana (Edoxaban)
| Teva-Edoxaban (Generic) Edoxaban | ||||||
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Shipped from Canada | ||||||
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General Medication Fact Sheet for Lixiana
| Field | Information |
|---|---|
| Medication Name | Lixiana |
| Generic Name | Edoxaban |
| Boxed/Label Warning | Premature discontinuation of any oral anticoagulant, including edoxaban, increases the risk of thrombotic events. Edoxaban is not recommended in patients with creatinine clearance >95 mL/min because of increased risk of ischemic stroke. |
| Purpose | Anticoagulant used to reduce the risk of stroke and systemic embolism in nonvalvular atrial fibrillation and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE). |
| Mechanism of Action | Directly inhibits factor Xa, a key enzyme in the coagulation cascade, preventing the formation of blood clots. |
| Dosage Forms | Oral tablets |
| Available Strengths | 15 mg, 30 mg, 60 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Bleeding (e.g., nosebleeds, bruising), anemia |
| Serious Side Effects | Major bleeding events (e.g., gastrointestinal bleeding, intracranial hemorrhage), allergic reactions |
| Drug Interactions | Other anticoagulants (e.g., warfarin, heparin), antiplatelet agents (e.g., aspirin, clopidogrel), certain antidepressants (SSRIs, SNRIs), NSAIDs, strong CYP3A4 inhibitors (e.g., ketoconazole), strong P-gp inhibitors (e.g., erythromycin). |
| Important Notes | Inform your doctor about all medications and supplements you are taking. Regular monitoring of kidney function may be required. Adherence to the prescribed dose is crucial. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember on the same day. Do not double the dose to make up for a missed dose. |
| Alternatives | Warfarin, Apixaban (Eliquis), Rivaroxaban (Xarelto), Dabigatran (Pradaxa) |
Lixiana Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Warfarin (Coumadin) | Vitamin K antagonist | Requires regular INR monitoring. |
| Apixaban (Eliquis) | Direct factor Xa inhibitor | Another non-vitamin K antagonist oral anticoagulant (NOAC). |
| Rivaroxaban (Xarelto) | Direct factor Xa inhibitor | Another NOAC, taken once daily. |
| Dabigatran (Pradaxa) | Direct thrombin inhibitor | A NOAC that works by inhibiting thrombin. |
Lixiana Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Bleeding (e.g., nosebleeds, bruising) | Major bleeding events (e.g., gastrointestinal bleeding, intracranial hemorrhage) |
| Anemia | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Skin rash | Thrombocytopenia (low platelet count) |
Lixiana Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Nonvalvular Atrial Fibrillation | 60 mg once daily | 60 mg once daily (may be reduced to 30 mg based on kidney function, body weight, or concomitant medications) | Swallow the tablet whole. May be taken with or without food. |
| DVT/PE Treatment | 60 mg once daily after initial treatment with a parenteral anticoagulant (e.g., heparin) for at least 5 days | 60 mg once daily (may be reduced to 30 mg based on kidney function, body weight, or concomitant medications) | Swallow the tablet whole. May be taken with or without food. |
