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General Medication Fact Sheet for Movantik
| Field | Information |
|---|---|
| Medication Name | Movantik |
| Generic Name | Naloxegol |
| Boxed/Label Warning | Risk of Opioid Withdrawal. Cases of gastrointestinal perforation have been reported. |
| Purpose | Treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain. |
| Mechanism of Action | Peripherally acting mu-opioid receptor antagonist. |
| Dosage Forms | Oral tablets |
| Available Strengths | 12.5 mg, 25 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Abdominal pain, diarrhea, nausea, flatulence, headache |
| Serious Side Effects | Opioid withdrawal symptoms, severe abdominal pain, vomiting, bowel perforation, hypersensitivity reactions |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), strong CYP3A4 inducers (e.g., rifampin, carbamazepine), opioids, drugs metabolized by UGT2B7 |
| Important Notes | Discontinue use if treatment with the opioid pain medication is stopped. Should not be used in patients with known or suspected mechanical gastrointestinal obstruction or at increased risk of recurrent obstruction. |
| Storage | Store at room temperature, away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Amitiza (lubiprostone), Linzess (linaclotide), Relistor (methylnaltrexone), Trulance (plecanatide) |
Movantik Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Amitiza (lubiprostone) | Chloride channel activator | Increases intestinal fluid secretion to soften stool and promote bowel movements. |
| Linzess (linaclotide) | Guanylate cyclase-C agonist | Increases intestinal fluid secretion and accelerates gastrointestinal transit. |
| Relistor (methylnaltrexone) | Peripherally acting mu-opioid receptor antagonist | Blocks opioid receptors in the gut to relieve constipation, administered via injection. |
| Trulance (plecanatide) | Guanylate cyclase-C agonist | Stimulates fluid secretion and promotes regular bowel movements. |
Movantik Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Abdominal pain | Opioid withdrawal symptoms (sweating, chills, diarrhea, anxiety) |
| Diarrhea | Severe abdominal pain |
| Nausea | Vomiting |
| Flatulence | Bowel perforation |
| Headache | Hypersensitivity reactions (rash, itching, swelling, difficulty breathing) |
Movantik Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Opioid-Induced Constipation | 25 mg | 25 mg once daily | Take on an empty stomach, at least 1 hour before a meal or 2 hours after a meal. |
| Opioid-Induced Constipation (Considered for patients unable to tolerate 25 mg) | 12.5 mg | 12.5 mg once daily | Take on an empty stomach, at least 1 hour before a meal or 2 hours after a meal. |
Movantik Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $150 – $350 |
| Without Insurance (U.S.) | $450- $550 |
| From Canada | $296.70 |
