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General Medication Fact Sheet for Mysoline
| Field | Information |
|---|---|
| Medication Name | Mysoline |
| Generic Name | Primidone |
| Boxed/Label Warning | May cause suicidal thoughts or actions in a small number of people. |
| Purpose | Anticonvulsant used to control seizures. |
| Mechanism of Action | Its mechanism is not completely understood, but it is believed to work by depressing neuronal excitability. |
| Dosage Forms | Oral tablets, oral suspension |
| Available Strengths | 50 mg, 250 mg |
| Dosage Frequency | Typically multiple times daily, as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dizziness, nausea, vomiting, ataxia (loss of coordination), fatigue. |
| Serious Side Effects | Suicidal thoughts or actions, severe allergic reactions, blood disorders (e.g., agranulocytosis, thrombocytopenia), liver problems. |
| Drug Interactions | Other anticonvulsants (e.g., Phenytoin, Carbamazepine), CNS depressants (e.g., alcohol, benzodiazepines), warfarin. |
| Important Notes | May cause drowsiness; use caution when driving or operating machinery. Regular blood tests may be needed. Do not stop taking suddenly without consulting your doctor. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Phenobarbital, Phenytoin, Carbamazepine, Valproic Acid, Gabapentin |
Mysoline Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Phenobarbital | Increases GABA-mediated inhibition. | Older anticonvulsant; can be very sedating. |
| Phenytoin (Dilantin) | Blocks voltage-gated sodium channels. | Requires monitoring of blood levels. |
| Carbamazepine (Tegretol) | Blocks voltage-gated sodium channels. | Can interact with many other medications. |
| Valproic Acid (Depakote) | Increases GABA levels and blocks sodium channels. | Used for various seizure types; potential for liver toxicity. |
| Gabapentin (Neurontin) | Binds to alpha2delta subunit of voltage-dependent calcium channels. | Also used for nerve pain. |
Mysoline Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | New or worsening depression or suicidal thoughts |
| Dizziness | Severe skin rash (Stevens-Johnson syndrome) |
| Nausea | Signs of a blood disorder (fever, sore throat, unusual bleeding or bruising, severe fatigue) |
| Vomiting | Signs of liver problems (jaundice, dark urine, abdominal pain) |
| Ataxia (loss of coordination) | Confusion or severe agitation |
Mysoline Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Seizures (Adults) | 100-125 mg at bedtime | 750-1500 mg daily in divided doses | Increase gradually to avoid excessive sedation. |
| Seizures (Children under 8) | 50 mg at bedtime | 125-250 mg three times daily | Dosage must be individualized. |
| Seizures (Children over 8) | 125 mg at bedtime | 250 mg three times daily or 10-25 mg/kg/day in divided doses | Dosage must be individualized. |
Mysoline Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 |
| Without Insurance (U.S.) | $80 – $250 |
| From CPS | $136.99 |
