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General Medication Fact Sheet for Nateglinide
| Field | Information |
|---|---|
| Generic Name | Nateglinide |
| Brand Name Versions | Starlix |
| Purpose | Used to treat type 2 diabetes by helping the pancreas release insulin. |
| Mechanism of Action | Stimulates insulin release from the pancreas by binding to ATP-sensitive potassium channels in pancreatic beta cells. |
| Dosage Forms | Oral tablets |
| Available Strengths | 60 mg, 120 mg, 180 mg |
| Dosage Frequency | Typically taken three times a day, 1-30 minutes before meals. |
| Common Side Effects | Hypoglycemia (low blood sugar), weight gain, upper respiratory infection, dizziness. |
| Serious Side Effects | Severe hypoglycemia, allergic reactions (rash, itching, swelling, difficulty breathing). |
| Drug Interactions | Gemfibrozil, NSAIDs, beta-blockers, corticosteroids, thiazide diuretics, ACE inhibitors. |
| Important Notes | Monitor blood sugar levels regularly; take before meals as directed; inform your doctor of any other medications or medical conditions. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Skip the missed dose and take your next dose before your next meal. Do not double the dose. |
| Alternatives | Repaglinide (Prandin), Metformin (Glucophage), Glipizide (Glucotrol), Sitagliptin (Januvia) |
Nateglinide Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Repaglinide (Prandin) | Stimulates insulin release from the pancreas. | Similar to nateglinide, but may have a shorter duration of action. |
| Metformin (Glucophage) | Decreases glucose production in the liver and improves insulin sensitivity. | A common first-line treatment for type 2 diabetes. |
| Glipizide (Glucotrol) | Stimulates insulin release from the pancreas. | A sulfonylurea that can cause hypoglycemia. |
| Sitagliptin (Januvia) | Inhibits DPP-4, increasing insulin release and decreasing glucagon secretion. | A DPP-4 inhibitor with a lower risk of hypoglycemia compared to sulfonylureas. |
Nateglinide Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hypoglycemia (low blood sugar) | Severe hypoglycemia (confusion, seizures, loss of consciousness) |
| Weight gain | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Upper respiratory infection | Signs of liver problems (jaundice, dark urine, severe stomach pain, persistent nausea) |
Nateglinide Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Type 2 Diabetes | 60 mg | 60 mg, 120 mg, or 180 mg three times daily | Take 1-30 minutes before meals. Dosage may be adjusted based on blood glucose levels. |
Nateglinide Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $70 – $180 |
| From CPS | $44.95 |
