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General Medication Fact Sheet for Nevirapine
| Field | Information |
|---|---|
| Generic Name | Nevirapine |
| Brand Name Versions | Viramune |
| Boxed/Label Warning | Serious, life-threatening skin reactions and liver damage have occurred in patients taking nevirapine. Patients should be closely monitored during the first 18 weeks of therapy. Nevirapine is not recommended for post-exposure prophylaxis. |
| Purpose | Non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection. |
| Mechanism of Action | Inhibits HIV-1 reverse transcriptase by binding directly to the enzyme and blocking RNA-dependent and DNA-dependent DNA polymerase activities. |
| Dosage Forms | Oral tablets, Oral suspension |
| Available Strengths | 200 mg (tablets), 50 mg/5 mL (suspension) |
| Dosage Frequency | Once daily for the first 14 days, then twice daily thereafter, or as directed by a healthcare provider. |
| Common Side Effects | Rash, nausea, fatigue, headache, abdominal pain |
| Serious Side Effects | Severe rash (Stevens-Johnson syndrome, toxic epidermal necrolysis), liver damage, allergic reactions |
| Drug Interactions | Many drugs interact with nevirapine, including hormonal contraceptives, other antiretrovirals (e.g., Efavirenz), some antifungals (e.g., ketoconazole), and some antibiotics (e.g., rifampin). |
| Important Notes | Must be taken in combination with other antiretroviral medications. Closely monitor for rash and liver function. Inform your doctor of all other medications you are taking. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Efavirenz, Etravirine, Rilpivirine, Doravirine |
Nevirapine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Efavirenz (Sustiva) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) | Another NNRTI, often used in first-line HIV treatment. |
| Etravirine (Intelence) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) | NNRTI used for HIV-1 in patients with resistance to other NNRTIs. |
| Rilpivirine (Edurant) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) | NNRTI, often used in combination pills with other antiretrovirals. |
| Doravirine (Pifeltro) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) | Newer NNRTI, often used in combination pills. |
Nevirapine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Rash | Severe rash (Stevens-Johnson syndrome, toxic epidermal necrolysis) |
| Nausea | Liver damage |
| Fatigue | Allergic reactions (angioedema, anaphylaxis) |
| Headache | Hepatitis |
| Abdominal pain | Increased risk of infections |
Nevirapine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV-1 Infection (Adults) | 200 mg once daily | 200 mg twice daily | Must be taken with other antiretroviral medications. Initial dose is once daily for 14 days, then increased to twice daily if no rash occurs. |
| HIV-1 Infection (Children) | Varies by weight | Varies by weight | Dosage is weight-based. Consult a healthcare provider for specific dosing information. |
Nevirapine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $50 – $120 |
| From CPS | $44.95 |
