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Nexavar (Sorafenib)
| Sorafenib Tosylate (Generic) Sorafenib Tosylate | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Nexavar
| Field | Information |
|---|---|
| Medication Name | Nexavar |
| Generic Name | Sorafenib |
| Boxed/Label Warning | Yes. Severe liver damage and increased risk of bleeding. |
| Purpose | Treatment of advanced renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer), and differentiated thyroid cancer. |
| Mechanism of Action | Inhibits multiple tyrosine kinases (including VEGFR and PDGFR), disrupting tumor cell growth and angiogenesis. |
| Dosage Forms | Oral tablets |
| Available Strengths | 200 mg |
| Dosage Frequency | Twice daily |
| Common Side Effects | Diarrhea, fatigue, hand-foot skin reaction, rash, weight loss, hypertension, alopecia. |
| Serious Side Effects | Hepatotoxicity, hemorrhage, hypertension, cardiac ischemia/infarction, arterial thromboembolic events, wound healing complications, tumor lysis syndrome. |
| Drug Interactions | Warfarin, rifampin, phenytoin, neomycin, doxorubicin. |
| Important Notes | Take on an empty stomach (at least 1 hour before or 2 hours after eating). Monitor liver function, blood pressure, and for signs of bleeding. Avoid pregnancy. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed, do not double the next dose. Take the next dose at the regularly scheduled time. |
| Alternatives | Sutent (sunitinib), Cabometyx (cabozantinib), Lenvima (lenvatinib). |
Nexavar Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sutent (sunitinib) | Tyrosine kinase inhibitor | Used for renal cell carcinoma, GIST, and pancreatic neuroendocrine tumors. |
| Cabometyx (cabozantinib) | Tyrosine kinase inhibitor | Used for renal cell carcinoma, hepatocellular carcinoma, and thyroid cancer. |
| Lenvima (lenvatinib) | Tyrosine kinase inhibitor | Used for thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. |
Nexavar Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Hepatotoxicity (liver damage) |
| Fatigue | Hemorrhage (bleeding) |
| Hand-foot skin reaction | Hypertension (high blood pressure) |
| Rash | Cardiac ischemia/infarction (heart problems) |
| Weight loss | Arterial thromboembolic events (blood clots) |
| Hypertension | Wound healing complications |
Nexavar Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Renal Cell Carcinoma | 400 mg | 400 mg twice daily | Take on an empty stomach, at least 1 hour before or 2 hours after a meal. |
| Hepatocellular Carcinoma | 400 mg | 400 mg twice daily | Take on an empty stomach, at least 1 hour before or 2 hours after a meal. |
| Differentiated Thyroid Cancer | 400 mg | 400 mg twice daily | Take on an empty stomach, at least 1 hour before or 2 hours after a meal. |
Nexavar Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $2,000 |
| Without Insurance (U.S.) | $25,000 |
| From CPS | $8,197.10 |
