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General Medication Fact Sheet for Nocdurna
| Field | Information |
|---|---|
| Medication Name | Nocdurna |
| Generic Name | Desmopressin Acetate |
| Boxed/Label Warning | Hyponatremia (low sodium levels) can occur, leading to seizures, coma, and death. Fluid restriction is recommended. |
| Purpose | Treatment of nocturia due to nocturnal polyuria in adults |
| Mechanism of Action | Synthetic analog of vasopressin; reduces urine production by increasing water reabsorption in the kidneys |
| Dosage Forms | Sublingual tablets |
| Available Strengths | 27.7 mcg, 55.3 mcg |
| Dosage Frequency | Once daily, one hour before bedtime |
| Common Side Effects | Headache, dry mouth, hyponatremia (low sodium), dizziness |
| Serious Side Effects | Severe hyponatremia (seizures, coma), fluid overload |
| Drug Interactions | NSAIDs, tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), chlorpromazine, carbamazepine, diuretics |
| Important Notes | Fluid intake should be limited from 1 hour before until 8 hours after administration. Monitor serum sodium levels. Use with caution in patients with conditions that can cause fluid or electrolyte imbalance. Not recommended for use in patients over 65 years of age due to increased risk of hyponatremia. |
| Storage | Store at room temperature, away from moisture and light. Keep out of reach of children. |
| Missed Dose | Skip the missed dose and take the next dose at the regularly scheduled time. Do not double the dose. |
| Alternatives | Desmopressin tablets (DDAVP), Imipramine, Tolterodine, Oxybutynin |
Nocdurna Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Desmopressin tablets (DDAVP) | Synthetic analog of vasopressin; increases water reabsorption in the kidneys | Tablet form of desmopressin; may be used for nocturnal enuresis and diabetes insipidus. |
| Imipramine (Tofranil) | Tricyclic antidepressant; anticholinergic properties can reduce bladder contractions | Used off-label for nocturnal enuresis; potential side effects include dry mouth and constipation. |
| Tolterodine (Detrol) | Muscarinic receptor antagonist; reduces bladder muscle contractions | Used for overactive bladder; may help reduce nocturia in some patients. |
| Oxybutynin (Ditropan) | Muscarinic receptor antagonist; reduces bladder muscle contractions | Used for overactive bladder; similar to Tolterodine with a higher incidence of side effects. |
Nocdurna Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Severe hyponatremia (seizures, coma) |
| Dry mouth | Fluid overload (swelling of extremities, weight gain) |
| Hyponatremia (low sodium levels) | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Nocdurna Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Nocturia due to nocturnal polyuria in adult women | 27.7 mcg | 27.7 mcg daily | Administer sublingually one hour before bedtime. Limit fluid intake from 1 hour before until 8 hours after administration. |
| Nocturia due to nocturnal polyuria in adult men | 55.3 mcg | 55.3 mcg daily | Administer sublingually one hour before bedtime. Limit fluid intake from 1 hour before until 8 hours after administration. |
Nocdurna Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $530 – $1,750 |
| From CPS | $93.95 |
