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General Medication Fact Sheet for Norpace
| Field | Information |
|---|---|
| Medication Name | Norpace |
| Generic Name | Disopyramide |
| Boxed/Label Warning | Norpace can cause new or worsening heart failure. May also cause potentially life-threatening abnormal heart rhythms (e.g., Torsades de Pointes). Proarrhythmic effects are more likely in patients with underlying heart disease or electrolyte imbalances. |
| Purpose | Used to treat and prevent certain irregular heartbeats (arrhythmias) such as ventricular tachycardia. |
| Mechanism of Action | Works by blocking sodium channels in the heart, which slows down electrical impulses and helps to regulate heart rhythm. |
| Dosage Forms | Oral capsules |
| Available Strengths | 100 mg, 150 mg |
| Dosage Frequency | Typically every 6-8 hours, as prescribed by a healthcare provider. |
| Common Side Effects | Dry mouth, urinary hesitancy, constipation, blurred vision, dry eyes. |
| Serious Side Effects | New or worsening heart failure, abnormal heart rhythms (e.g., Torsades de Pointes), low blood pressure, glaucoma, urinary retention. |
| Drug Interactions | Other antiarrhythmic drugs (e.g., quinidine, procainamide), anticholinergic medications, medications that prolong the QT interval, beta-blockers, calcium channel blockers. |
| Important Notes | Use with caution in patients with heart failure, glaucoma, urinary retention, or kidney/liver problems. Regular monitoring of ECG and electrolytes is important. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Amiodarone, Sotalol, Propafenone, Flecainide. |
Norpace Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Amiodarone (Cordarone, Pacerone) | Potassium, sodium, and calcium channel blocker; also blocks adrenergic receptors. | Broad-spectrum antiarrhythmic, but has significant side effects and requires monitoring. |
| Sotalol (Betapace) | Beta-adrenergic blocker and potassium channel blocker. | Used for both supraventricular and ventricular arrhythmias; can prolong QT interval. |
| Propafenone (Rythmol) | Sodium channel blocker with some beta-blocking activity. | Used for supraventricular arrhythmias; can cause proarrhythmic effects. |
| Flecainide (Tambocor) | Sodium channel blocker. | Effective for supraventricular arrhythmias; should be used with caution in patients with structural heart disease. |
Norpace Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | New or worsening heart failure |
| Urinary hesitancy | Abnormal heart rhythms (Torsades de Pointes) |
| Constipation | Low blood pressure |
| Blurred vision | Glaucoma |
| Dry eyes | Urinary retention |
Norpace Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Ventricular Arrhythmias | 100-200 mg | 150 mg every 6 hours or 200 mg every 8 hours | Administer on an empty stomach if possible to enhance absorption. Dosage adjustments should be made based on patient response and tolerance, under the supervision of a healthcare provider. |
Norpace Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $60 |
| Without Insurance (U.S.) | $400 – $600 |
| From CPS | $46.95 |
