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Odefsey (Emtricitabine , Rilpivirine , Tenofovir Alafenamide)
General Medication Fact Sheet for Odefsey
| Field | Information |
|---|---|
| Medication Name | Odefsey |
| Generic Name | Emtricitabine / Rilpivirine / Tenofovir Alafenamide |
| Boxed/Label Warning | Post-Treatment Acute Exacerbation of Hepatitis B in Patients Coinfected with HIV-1 and HBV |
| Purpose | Treatment of HIV-1 infection in adults and pediatric patients weighing at least 77 lbs (35 kg) |
| Mechanism of Action | Reverse transcriptase inhibitors; inhibits HIV-1 replication |
| Dosage Forms | Oral tablet |
| Available Strengths | 200 mg / 25 mg / 25 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Depression, insomnia, headache, nausea, diarrhea |
| Serious Side Effects | Severe depression or mood changes, kidney problems, liver problems, lactic acidosis |
| Drug Interactions | Certain antiarrhythmics, anticonvulsants, rifamycins, St. John’s Wort, other antiretrovirals |
| Important Notes | Take with a meal; avoid missing doses; monitor for signs of liver or kidney problems |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember, with food. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose. |
| Alternatives | Genvoya, Biktarvy, Triumeq, Dovato |
Odefsey Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) | Integrase strand transfer inhibitor (INSTI) / CYP3A inhibitor / Reverse transcriptase inhibitors | A complete regimen in a single tablet; contains a different INSTI. |
| Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) | Integrase strand transfer inhibitor (INSTI) / Reverse transcriptase inhibitors | A complete regimen in a single tablet; contains a different INSTI. |
| Triumeq (dolutegravir/abacavir/lamivudine) | Integrase strand transfer inhibitor (INSTI) / Reverse transcriptase inhibitors | A complete regimen in a single tablet; contains different reverse transcriptase inhibitors. Requires HLA-B*5701 testing before initiation. |
| Dovato (dolutegravir/lamivudine) | Integrase strand transfer inhibitor (INSTI) / Reverse transcriptase inhibitor | A complete regimen in a single tablet, but only appropriate for certain patient populations. |
Odefsey Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Depression | Severe depression or mood changes |
| Insomnia | Kidney problems |
| Headache | Liver problems |
| Nausea | Lactic acidosis |
| Diarrhea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Odefsey Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV-1 Infection | One tablet | One tablet once daily | Take with a meal. |
Odefsey Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $3,000 – $3,200 |
| From Canada | $1,500 |
