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General Medication Fact Sheet for Olumiant
| Field | Information |
|---|---|
| Medication Name | Olumiant |
| Generic Name | Baricitinib |
| Boxed/Label Warning | Increased risk of serious infections, malignancies, and thrombosis. |
| Purpose | Treatment of rheumatoid arthritis (RA), alopecia areata, and COVID-19 in certain hospitalized adults. |
| Mechanism of Action | Janus kinase (JAK) inhibitor; interferes with the JAK-STAT signaling pathway. |
| Dosage Forms | Oral tablets |
| Available Strengths | 1 mg, 2 mg, 4 mg |
| Dosage Frequency | Once daily, with or without food. |
| Common Side Effects | Upper respiratory tract infections (e.g., common cold, sore throat), nausea, herpes zoster (shingles), headache. |
| Serious Side Effects | Serious infections (e.g., pneumonia, cellulitis), blood clots, malignancies (lymphoma), gastrointestinal perforations, liver problems, changes in blood counts. |
| Drug Interactions | Probenecid, other immunosuppressants (e.g., azathioprine, cyclosporine), biologic DMARDs (e.g., adalimumab, etanercept). |
| Important Notes | Inform your doctor of any history of infections, blood clots, or liver problems. Avoid live vaccines during treatment. Monitor for signs of infection. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Tofacitinib (Xeljanz), Adalimumab (Humira), Methotrexate, Etanercept (Enbrel) |
Olumiant Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tofacitinib (Xeljanz) | JAK inhibitor | Another JAK inhibitor used for rheumatoid arthritis and other conditions. |
| Adalimumab (Humira) | TNF-alpha inhibitor | A biologic DMARD; blocks TNF-alpha, a protein involved in inflammation. |
| Methotrexate | Antimetabolite and DMARD | A common first-line treatment for rheumatoid arthritis. |
| Etanercept (Enbrel) | TNF-alpha inhibitor | Another biologic DMARD that blocks TNF-alpha. |
Olumiant Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory tract infections | Serious infections (pneumonia, sepsis) |
| Nausea | Blood clots (deep vein thrombosis, pulmonary embolism) |
| Headache | Malignancies (lymphoma) |
| Herpes zoster (shingles) | Gastrointestinal perforations |
| Increased cholesterol levels | Liver problems |
Olumiant Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 2 mg or 4 mg once daily | 2 mg or 4 mg once daily (lowest effective dose) | May be used as monotherapy or in combination with Methotrexate or other non-biologic DMARDs. |
| Alopecia Areata | 2 mg once daily | 2 mg once daily, may increase to 4 mg if needed | Monitor for response; discontinue if no response after 36 weeks. |
| COVID-19 (Hospitalized Adults) | 4 mg once daily | 4 mg once daily for 14 days or until hospital discharge | Used in combination with remdesivir. |
Olumiant Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $200 |
| Without Insurance (U.S.) | $2,200 – $2,700 |
| From CPS | $2,588.01 |
