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General Medication Fact Sheet for Omeprazole
| Field | Information |
|---|---|
| Generic Name | Omeprazole |
| Brand Name Versions | Prilosec |
| Purpose | Proton pump inhibitor (PPI) used to reduce stomach acid production |
| Mechanism of Action | Inhibits the H+/K+ ATPase proton pump in gastric parietal cells |
| Dosage Forms | Oral capsules, oral tablets (including delayed-release) |
| Available Strengths | 10 mg, 20 mg, 40 mg |
| Dosage Frequency | Typically once daily, before a meal |
| Common Side Effects | Headache, nausea, diarrhea, abdominal pain |
| Serious Side Effects | Increased risk of bone fractures, vitamin B12 deficiency, kidney problems, lupus |
| Drug Interactions | Clopidogrel, warfarin, digoxin, methotrexate, certain antifungals (e.g., ketoconazole), certain HIV medications |
| Important Notes | Take before meals; do not crush or chew delayed-release capsules; long-term use may have risks |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Pantoprazole, Esomeprazole, Lansoprazole, Ranitidine, Famotidine |
Omeprazole Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Pantoprazole (Protonix) | Proton pump inhibitor | Another PPI with similar uses as omeprazole. |
| Esomeprazole (Nexium) | Proton pump inhibitor | S-isomer of omeprazole, also a PPI. |
| Lansoprazole (Prevacid) | Proton pump inhibitor | Another PPI, available in various formulations. |
| Ranitidine (Zantac) | H2 receptor antagonist | Reduces stomach acid production; generally less potent than PPIs (Note: Ranitidine has been recalled in some regions due to safety concerns; consult with a healthcare provider). |
| Famotidine (Pepcid) | H2 receptor antagonist | Another H2 receptor antagonist, similar to Ranitidine. |
Omeprazole Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Increased risk of bone fractures |
| Nausea | Vitamin B12 deficiency |
| Diarrhea | Kidney problems |
| Abdominal pain | Lupus |
| Gas | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
Omeprazole Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| GERD | 20 mg | 20 mg once daily | Take before a meal. |
| Erosive Esophagitis | 20-40 mg | 20 mg once daily | Take before a meal. |
| Peptic Ulcer Disease | 20-40 mg | 20 mg once daily | Take before a meal. |
| Zollinger-Ellison Syndrome | 60 mg | Individualized; up to 120 mg daily | Divide doses if higher than 80 mg/day. |
Omeprazole Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $10 – $35 |
| From CPS | $10 |
