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General Medication Fact Sheet for Ongentys
| Field | Information |
|---|---|
| Medication Name | Ongentys |
| Generic Name | Opicapone |
| Purpose | Used as an add-on treatment to levodopa/carbidopa in patients with Parkinson’s disease experiencing “off” episodes. |
| Mechanism of Action | Selective and reversible catechol-O-methyltransferase (COMT) inhibitor, which helps to prevent the breakdown of levodopa, thereby prolonging its effect. |
| Dosage Forms | Oral capsules |
| Available Strengths | 50 mg |
| Dosage Frequency | Once daily at bedtime. |
| Common Side Effects | Dyskinesia, constipation, blood creatine kinase increased, hypotension, weight decrease. |
| Serious Side Effects | Hallucinations, psychotic behavior, impulse control disorders. |
| Drug Interactions | COMT inhibitors, MAO inhibitors, drugs metabolized by COMT (e.g., isoproterenol, epinephrine). |
| Important Notes | Take at bedtime and at least one hour before or after levodopa/carbidopa. Monitor for dyskinesias, hallucinations, and impulse control disorders. |
| Storage | Store at room temperature between 68°F to 77°F (20°C to 25°C). Protect from moisture. |
| Missed Dose | If you miss a dose, take it as soon as you remember that day. If you don’t remember until the next day, skip the missed dose and continue with your regular schedule. Do not double your dose. |
| Alternatives | Entacapone (Comtan), Tolcapone (Tasmar), Istradefylline (Nourianz) |
Ongentys Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Entacapone (Comtan) | COMT inhibitor | Shorter duration of action compared to opicapone; needs to be taken with each dose of levodopa/carbidopa. |
| Tolcapone (Tasmar) | COMT inhibitor | More potent than Entacapone but carries a risk of liver toxicity, requiring regular liver function monitoring. |
| Istradefylline (Nourianz) | Adenosine A2A receptor antagonist | Works through a different mechanism to reduce “off” episodes in Parkinson’s disease. |
Ongentys Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dyskinesia | Hallucinations |
| Constipation | Psychotic behavior |
| Blood creatine kinase increased | Impulse control disorders (e.g., compulsive gambling, increased sexual urges) |
| Hypotension | Neuroleptic Malignant Syndrome (NMS) |
| Weight decrease | Rhabdomyolysis |
Ongentys Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease (with “off” episodes) | 50 mg | 50 mg once daily | Take at bedtime, at least one hour before or after levodopa/carbidopa. |
Ongentys Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $500 |
| Without Insurance (U.S.) | $1200 |
| From Canada | $900 |
