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Onglyza (Saxagliptin)
| Saxagliptin Hydrochloride (Generic) Saxagliptin Hydrochloride | ||||||
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Shipped from Canada | ||||||
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General Medication Fact Sheet for Onglyza
| Field | Information |
|---|---|
| Medication Name | Onglyza |
| Generic Name | Saxagliptin |
| Boxed/Label Warning | May cause serious allergic reactions, sometimes severe. |
| Purpose | Used to treat type 2 diabetes mellitus, along with diet and exercise, to lower blood sugar levels. |
| Mechanism of Action | Inhibits dipeptidyl peptidase-4 (DPP-4), increasing incretin levels, which stimulate insulin release and decrease glucagon secretion. |
| Dosage Forms | Oral tablets |
| Available Strengths | 2.5 mg, 5 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Upper respiratory tract infection, urinary tract infection, headache, nausea |
| Serious Side Effects | Pancreatitis, heart failure, severe joint pain, allergic reactions (rash, itching, swelling), bullous pemphigoid |
| Drug Interactions | Insulin, sulfonylureas (e.g., glipizide, glyburide), CYP3A4/5 inhibitors (e.g., ketoconazole, clarithromycin), CYP3A4/5 inducers (e.g., rifampin, phenytoin) |
| Important Notes | Not for use in type 1 diabetes or diabetic ketoacidosis. Use with caution in patients with kidney problems or a history of pancreatitis. Can cause hypoglycemia when used with insulin or sulfonylureas. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Januvia (sitagliptin), Tradjenta (linagliptin), Jardiance (empagliflozin), Metformin |
Onglyza Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Januvia (sitagliptin) | DPP-4 inhibitor | Similar mechanism of action to Onglyza; another DPP-4 inhibitor. |
| Tradjenta (linagliptin) | DPP-4 inhibitor | Another DPP-4 inhibitor; may have different interactions or side effect profiles. |
| Jardiance (empagliflozin) | SGLT2 inhibitor | Works by increasing glucose excretion in the urine. Offers cardiovascular benefits in some patients. |
| Metformin | Biguanide; decreases glucose production in the liver and improves insulin sensitivity. | First-line treatment for type 2 diabetes. |
Onglyza Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory tract infection | Pancreatitis |
| Urinary tract infection | Heart failure |
| Headache | Severe joint pain |
| Nausea | Allergic reactions (rash, itching, swelling) |
| Swelling of ankles or feet (peripheral edema) | Bullous pemphigoid (a skin condition) |
Onglyza Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Type 2 Diabetes Mellitus | 2.5 mg or 5 mg | 2.5 mg or 5 mg once daily | May be taken with or without food. Dosage depends on kidney function. |
Onglyza Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $100 |
| Without Insurance (U.S.) | $580 – $700 |
| From CPS | $72.50 |
