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General Medication Fact Sheet for Onstryv
| Field | Information |
|---|---|
| Medication Name | Onstryv |
| Generic Name | Safinamide |
| Purpose | Used to treat Parkinson’s disease in people who are already taking levodopa/carbidopa. |
| Mechanism of Action | Safinamide is a monoamine oxidase B (MAO-B) inhibitor and a sodium channel blocker. It works by increasing dopamine levels in the brain and blocking the release of glutamate. |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg, 100 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Dyskinesia (uncontrolled movements), nausea, insomnia, falls, constipation |
| Serious Side Effects | Serotonin syndrome (high fever, agitation, confusion, tremors, sweating, diarrhea), high blood pressure, hallucinations, retinal degeneration |
| Drug Interactions | MAO inhibitors, antidepressants (SSRIs, SNRIs, TCAs), opioids (meperidine, tramadol), sympathomimetic drugs (pseudoephedrine), St. John’s Wort |
| Important Notes | Inform your doctor of all medications you are taking. Monitor blood pressure regularly. Use caution when driving or operating machinery until you know how this medication affects you. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Selegiline, Rasagiline, Amantadine, Entacapone |
Onstryv Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Selegiline (Eldepryl) | Selective MAO-B inhibitor | May improve motor symptoms in early Parkinson’s disease or as an adjunct to levodopa. |
| Rasagiline (Azilect) | Selective MAO-B inhibitor | Used as monotherapy in early Parkinson’s disease or as an adjunct to levodopa. |
| Amantadine (Gocovri) | NMDA receptor antagonist | May help reduce dyskinesias (involuntary movements) in patients taking levodopa. |
| Entacapone (Comtan) | COMT inhibitor | Prolongs the effect of levodopa by blocking its breakdown. |
Onstryv Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dyskinesia (uncontrolled movements) | Serotonin syndrome (high fever, agitation, confusion, tremors, sweating, diarrhea) |
| Nausea | High blood pressure |
| Insomnia | Hallucinations |
| Falls | Retinal degeneration |
| Constipation | Worsening of pre-existing psychosis |
Onstryv Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease (Adjunct to Levodopa/Carbidopa) | 50 mg once daily | 100 mg once daily (may increase after two weeks) | Take with or without food. |
Onstryv Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $ |
| Without Insurance (U.S.) | $ |
| From CPS | $ |
