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General Medication Fact Sheet for Oralair
| Field | Information |
|---|---|
| Medication Name | Oralair |
| Generic Name | Mixed Grass Pollens Allergen Extract |
| Boxed/Label Warning | Severe allergic reactions (including anaphylaxis) can occur. Prescribe epinephrine and instruct patients on its appropriate use. Oralair is not interchangeable with other grass pollen extracts. |
| Purpose | Allergen immunotherapy for the treatment of grass pollen-induced allergic rhinitis, with or without conjunctivitis, in adults and children 5 years of age and older. |
| Mechanism of Action | Oralair works by gradually exposing the body to small doses of grass pollen allergens, leading to desensitization and reduced allergic reactions upon natural exposure. |
| Dosage Forms | Sublingual tablets |
| Available Strengths | 100 IR, 300 IR |
| Dosage Frequency | One tablet daily |
| Common Side Effects | Oral pruritus (itching of the mouth), throat irritation, ear pruritus (itching of the ears), mouth edema (swelling), tongue edema (swelling) |
| Serious Side Effects | Anaphylaxis, severe allergic reactions, eosinophilic esophagitis |
| Drug Interactions | Beta-blockers (may reduce the effectiveness of epinephrine), MAO inhibitors, tricyclic antidepressants, antihistamines (may interfere with allergy testing) |
| Important Notes | Administer the first tablet under medical supervision. Monitor patients for signs and symptoms of systemic allergic reactions. Not for use in patients with severe, unstable, or uncontrolled asthma. |
| Storage | Store in the refrigerator (36°F to 46°F [2°C to 8°C]) until use. |
| Missed Dose | If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once. |
| Alternatives | Grastek, Ragwitek, Immunotherapy injections, Antihistamines (e.g., loratadine, cetirizine) |
Oralair Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Grastek | Sublingual immunotherapy; similar mechanism of action | For Timothy grass pollen allergy. |
| Ragwitek | Sublingual immunotherapy; similar mechanism of action | For short ragweed pollen allergy. |
| Allergy Immunotherapy Injections (Allergy Shots) | Gradual exposure to allergens via injection | Requires frequent visits to a healthcare provider. |
| Loratadine (Claritin) | Antihistamine; blocks histamine receptors | Provides symptomatic relief; does not address the underlying allergy. |
Oralair Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Oral pruritus (itching of the mouth) | Anaphylaxis |
| Throat irritation | Severe allergic reactions (hives, angioedema, difficulty breathing) |
| Ear pruritus (itching of the ears) | Eosinophilic esophagitis |
| Mouth edema (swelling) | Worsening of asthma or an asthma attack |
| Tongue edema (swelling) | Severe swelling of the throat (laryngeal edema) |
Oralair Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Grass Pollen Allergy | Initiate treatment 4 months before the grass pollen season | One tablet (100 IR on day 1, increasing to 300 IR on day 2) daily throughout the grass pollen season | Administer the first tablet under medical supervision. Hold the tablet under the tongue until dissolved. Do not swallow for at least 1 minute. Avoid eating or drinking for 5 minutes after administration. |
Oralair Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $150 |
| Without Insurance (U.S.) | $650 – $750 |
| From CPS | $164.95 |
