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General Medication Fact Sheet for Orgalutran
| Field | Information |
|---|---|
| Medication Name | Orgalutran |
| Generic Name | Ganirelix Acetate |
| Purpose | Prevents premature ovulation during controlled ovarian hyperstimulation (COH) for assisted reproduction technologies (ART). |
| Mechanism of Action | GnRH antagonist; competitively blocks GnRH receptors in the pituitary gland, suppressing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 250 mcg/0.5 mL |
| Dosage Frequency | Once daily, typically during the mid to late follicular phase of COH. |
| Common Side Effects | Injection site reactions (redness, swelling, bruising), abdominal pain, headache, nausea. |
| Serious Side Effects | Ovarian hyperstimulation syndrome (OHSS), ectopic pregnancy. |
| Drug Interactions | No significant drug interactions reported, but consult with a healthcare provider about all medications and supplements being taken. |
| Important Notes | Administer subcutaneous injections as instructed by a healthcare provider. Monitor for signs of OHSS. |
| Storage | Store refrigerated between 2-8°C (36-46°F). Protect from light. |
| Missed Dose | Contact your doctor immediately for instructions. Do not administer a double dose. |
| Alternatives | Cetrotide (cetrorelix), Lupron (leuprolide), Synarel (nafarelin) |
Orgalutran Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Cetrotide (cetrorelix) | GnRH antagonist | Similar mechanism of action to Orgalutran; also used to prevent premature ovulation. |
| Lupron (leuprolide) | GnRH agonist | Works by initially stimulating, then suppressing, gonadotropin release. Requires a different protocol than GnRH antagonists. |
| Synarel (nafarelin) | GnRH agonist | A nasal spray used for pituitary suppression, requires a different protocol than GnRH antagonists. |
Orgalutran Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (redness, swelling, bruising) | Ovarian Hyperstimulation Syndrome (OHSS) |
| Abdominal pain | Ectopic pregnancy |
| Headache | Ovarian Torsion |
| Nausea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Orgalutran Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Prevention of premature ovulation during COH | 250 mcg | 250 mcg once daily | Administer subcutaneously once daily during the mid to late follicular phase. Start on day 5 or 6 of stimulation or when adequate follicular stimulation is evident. |
Orgalutran Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $300 |
| Without Insurance (U.S.) | $600 – $1,200 |
| From CPS | $149.15 |
