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General Medication Fact Sheet for Orgovyx
| Field | Information |
|---|---|
| Medication Name | Orgovyx |
| Generic Name | Relugolix |
| Purpose | Androgen deprivation therapy for advanced prostate cancer |
| Mechanism of Action | GnRH receptor antagonist, reducing testosterone production |
| Dosage Forms | Oral tablets |
| Available Strengths | 120 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Hot flashes, fatigue, constipation, diarrhea, arthralgia, musculoskeletal pain, decreased libido, increased glucose, increased triglycerides, increased cholesterol |
| Serious Side Effects | QTc prolongation, cardiovascular events, hypersensitivity reactions, liver enzyme elevations |
| Drug Interactions | Drugs that prolong the QTc interval, P-gp inhibitors, sensitive CYP3A substrates |
| Important Notes | Monitor for QTc prolongation; consider ECG monitoring if risk factors are present. Monitor liver function tests. Advise patients to report any symptoms of cardiovascular events. |
| Storage | Store at room temperature between 68°F to 77°F (20°C to 25°C). |
| Missed Dose | Take the dose as soon as you remember that day. If a dose is missed, do not take two doses to make up for the missed dose. |
| Alternatives | Leuprolide, Goserelin, Triptorelin, Bicalutamide |
Orgovyx Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Leuprolide (Lupron) | GnRH receptor agonist | Administered via injection; causes initial surge in testosterone, followed by downregulation. |
| Goserelin (Zoladex) | GnRH receptor agonist | Administered via subcutaneous implant; similar mechanism to leuprolide. |
| Triptorelin (Trelstar) | GnRH receptor agonist | Administered via injection; another GnRH agonist option. |
| Bicalutamide (Casodex) | Androgen receptor antagonist | Blocks the effects of androgens at the receptor level; often used in combination with a GnRH agonist. |
Orgovyx Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hot flashes | QTc prolongation |
| Fatigue | Cardiovascular events (e.g., heart attack, stroke) |
| Constipation | Hypersensitivity reactions (e.g., rash, angioedema) |
| Diarrhea | Liver enzyme elevations |
| Arthralgia | |
| Musculoskeletal pain | |
| Decreased libido | |
| Increased glucose | |
| Increased triglycerides | |
| Increased cholesterol |
Orgovyx Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Advanced Prostate Cancer | 360 mg on the first day | 120 mg once daily | Take orally at approximately the same time each day. Can be taken with or without food. |
Orgovyx Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 – $300 |
| Without Insurance (U.S.) | $1,100 – $1,300 |
| From CPS | $425.25 |
