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General Medication Fact Sheet for Orilissa
| Field | Information |
|---|---|
| Medication Name | Orilissa |
| Generic Name | Elagolix |
| Boxed/Label Warning | May cause bone loss. Limit treatment duration to 24 months due to bone mineral density decline. |
| Purpose | Management of moderate to severe endometriosis pain |
| Mechanism of Action | GnRH receptor antagonist that decreases estrogen production |
| Dosage Forms | Oral tablets |
| Available Strengths | 150 mg, 200 mg |
| Dosage Frequency | Once or twice daily, depending on the strength and indication |
| Common Side Effects | Hot flashes, night sweats, headache, nausea, insomnia, anxiety, mood changes, decreased libido, joint pain |
| Serious Side Effects | Bone loss (osteoporosis), suicidal thoughts or behavior, liver problems, elevated liver enzymes |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), CYP3A4 inducers (e.g., rifampin), certain hormonal contraceptives |
| Important Notes | Use effective non-hormonal contraception while taking Orilissa. Monitor for mood changes and bone mineral density, especially with long-term use. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Leuprolide (Lupron Depot), Goserelin (Zoladex), Norethindrone, Combined Oral Contraceptives, Danazol |
Orilissa Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Leuprolide (Lupron Depot) | GnRH agonist | Requires injections, may cause significant menopausal symptoms. |
| Goserelin (Zoladex) | GnRH agonist | Requires injections, may cause significant menopausal symptoms. |
| Norethindrone | Progestin | May help reduce pain and bleeding associated with endometriosis. |
| Combined Oral Contraceptives | Estrogen and progestin | Can help manage pain and regulate menstrual cycles. |
| Danazol | Synthetic steroid | Androgenic side effects are common; less frequently used now. |
Orilissa Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hot flashes | Bone loss (osteoporosis) |
| Night sweats | Suicidal thoughts or behavior |
| Headache | Liver problems, elevated liver enzymes |
| Nausea | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Insomnia | Mood changes (depression, anxiety) |
Orilissa Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Endometriosis Pain | 150 mg once daily | 150 mg once daily (up to 24 months) | May be taken with or without food. |
| Endometriosis Pain | 200 mg twice daily | 200 mg twice daily (up to 6 months) | May be taken with or without food. Consider only if other treatments are unsuitable. |
Orilissa Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 – $300 |
| Without Insurance (U.S.) | $1,400 – $1,550 |
| From CPS | $291.90 |
