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General Medication Fact Sheet for Orphenadrine
| Field | Information |
|---|---|
| Generic Name | Orphenadrine |
| Brand Name Versions | Norflex, Disipal (no longer available in the US) |
| Purpose | Muscle relaxant used to relieve muscle spasms and pain |
| Mechanism of Action | Anticholinergic properties that help to relax muscles |
| Dosage Forms | Oral tablets, Extended-release tablets, Injection |
| Available Strengths | 100 mg, 50mg (Injection) |
| Dosage Frequency | Typically twice daily, or as directed by a healthcare provider |
| Common Side Effects | Dry mouth, blurred vision, dizziness, drowsiness, constipation |
| Serious Side Effects | Fast heartbeat, difficulty urinating, confusion, hallucinations |
| Drug Interactions | Anticholinergics, MAO inhibitors, certain antihistamines, tricyclic antidepressants |
| Important Notes | Use caution when driving or operating machinery; avoid alcohol; may worsen glaucoma |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Cyclobenzaprine, Methocarbamol, Tizanidine |
Orphenadrine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Cyclobenzaprine (Flexeril) | Acts primarily within the central nervous system to reduce muscle spasm | Commonly used for short-term relief of muscle spasms. |
| Methocarbamol (Robaxin) | General CNS depressant with sedative and skeletal muscle relaxant properties | May cause drowsiness; use with caution. |
| Tizanidine (Zanaflex) | Alpha-2 adrenergic agonist that reduces muscle spasticity | Can cause hypotension and drowsiness. |
Orphenadrine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | Fast heartbeat |
| Blurred vision | Difficulty urinating |
| Dizziness | Confusion |
| Drowsiness | Hallucinations |
| Constipation | Severe allergic reaction (rash, itching, swelling, difficulty breathing) |
Orphenadrine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Muscle Spasms | 100 mg | 100 mg twice daily | Take as directed by your healthcare provider. |
