Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
General Medication Fact Sheet for Osphena
| Field | Information |
|---|---|
| Medication Name | Osphena |
| Generic Name | Ospemifene |
| Boxed/Label Warning | May increase the risk of endometrial cancer, stroke, and deep vein thrombosis (DVT). |
| Purpose | Treatment of moderate to severe dyspareunia (painful sexual intercourse), a symptom of vulvar and vaginal atrophy due to menopause. |
| Mechanism of Action | Selective estrogen receptor modulator (SERM) with estrogen agonist effects on the vaginal tissue. |
| Dosage Forms | Oral tablets |
| Available Strengths | 60 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Hot flashes, vaginal discharge, muscle spasms, excessive sweating. |
| Serious Side Effects | Stroke, deep vein thrombosis (DVT), pulmonary embolism, endometrial cancer, vaginal bleeding. |
| Drug Interactions | Estrogens, fluconazole, ketoconazole, rifampin, other SERMs (e.g., tamoxifen, raloxifene). |
| Important Notes | Not for use in women with a history of thromboembolic disease (e.g., DVT, pulmonary embolism), unexplained vaginal bleeding, or known endometrial cancer. Use with caution in women at risk for stroke or heart disease. Consult a healthcare provider for regular check-ups. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Vaginal estrogen creams (e.g., Premarin, Estrace), estrogen vaginal rings (e.g., Estring, Femring), lubricants, moisturizers. |
Osphena Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Vaginal Estrogen Cream (Premarin, Estrace) | Estrogen receptor agonist in vaginal tissue. | Topical application, local effects, lower systemic exposure. |
| Estrogen Vaginal Ring (Estring, Femring) | Estrogen receptor agonist in vaginal tissue. | Inserted vaginally, provides continuous low-dose estrogen. |
| Vaginal Moisturizers (Replens, Luvena) | Non-hormonal, provides lubrication and hydration. | Symptomatic relief of vaginal dryness. |
| Vaginal Lubricants | Provides lubrication during sexual activity. | Temporary relief of dyspareunia. |
Osphena Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hot flashes | Stroke |
| Vaginal discharge | Deep vein thrombosis (DVT) |
| Muscle spasms | Pulmonary embolism |
| Excessive sweating | Endometrial cancer |
| Nausea | Vaginal bleeding |
Osphena Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Dyspareunia (Painful Sexual Intercourse) | 60 mg | 60 mg once daily | Take orally with or without food. |
Osphena Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $150 |
| Without Insurance (U.S.) | $700 – $900 |
| From CPS | $73.40 |
