| Medication Name | Ovestin HRT Cream |
| Generic Name | Estriol |
| Boxed/Label Warning | Estrogen-Alone Therapy: Increased risk of endometrial cancer, stroke, and deep vein thrombosis (DVT). Use at the lowest effective dose for the shortest duration consistent with treatment goals. |
| Purpose | Hormone replacement therapy (HRT) to treat vaginal atrophy due to estrogen deficiency. |
| Mechanism of Action | Estriol, a type of estrogen, binds to estrogen receptors in vaginal tissues, helping to restore the thickness and elasticity of the vaginal lining. |
| Dosage Forms | Vaginal cream |
| Available Strengths | 0.1% (1 mg estriol per gram of cream) |
| Dosage Frequency | Typically once daily for the first few weeks, then reduced to once or twice weekly, as directed by a healthcare provider. |
| Common Side Effects | Vaginal itching or irritation, mild vaginal bleeding or spotting, breast tenderness, abdominal pain. |
| Serious Side Effects | Unusual vaginal bleeding, severe abdominal pain, vision changes, signs of blood clots (chest pain, shortness of breath, leg pain), jaundice (yellowing of skin or eyes). |
| Drug Interactions | Certain medications may affect how estriol works, including corticosteroids, thyroid hormones, and other hormone therapies. Inform your doctor of all medications you are taking. |
| Important Notes | Use with caution if you have a history of breast cancer, uterine cancer, blood clots, heart disease, or liver disease. Regular check-ups with your doctor are essential while using this medication. |
| Storage | Store at room temperature away from moisture and heat. |
| Missed Dose | If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Estradiol vaginal cream, Conjugated estrogens vaginal cream, Vagifem (estradiol vaginal tablets), Osphena (ospemifene) |