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General Medication Fact Sheet for Oxaprozin
| Field | Information |
|---|---|
| Generic Name | Oxaprozin |
| Brand Name Versions | Daypro |
| Boxed/Label Warning | NSAIDs may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. NSAIDs may also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. |
| Purpose | Non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation |
| Mechanism of Action | Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis |
| Dosage Forms | Oral tablets |
| Available Strengths | 600 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider |
| Common Side Effects | Dyspepsia, nausea, abdominal pain, constipation, diarrhea, headache, dizziness, rash |
| Serious Side Effects | Gastrointestinal bleeding, liver problems, kidney problems, heart attack, stroke, allergic reactions |
| Drug Interactions | Other NSAIDs, anticoagulants (e.g., warfarin), aspirin, ACE inhibitors, diuretics, lithium |
| Important Notes | Take with food to minimize stomach upset; consult a doctor if you have heart, liver, or kidney problems; avoid alcohol |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Ibuprofen, Naproxen, Celecoxib, Meloxicam |
Oxaprozin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ibuprofen (Advil, Motrin) | Non-selective COX inhibitor | Commonly used for mild to moderate pain relief. |
| Naproxen (Aleve) | Non-selective COX inhibitor | Longer-lasting pain relief compared to ibuprofen. |
| Celecoxib (Celebrex) | Selective COX-2 inhibitor | May have a lower risk of gastrointestinal side effects compared to non-selective NSAIDs. |
| Meloxicam (Mobic) | Preferentially inhibits COX-2 over COX-1 | Once-daily NSAID, may have a lower risk of GI side effects than some non-selective NSAIDs. |
Oxaprozin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dyspepsia | Gastrointestinal bleeding |
| Nausea | Liver problems |
| Abdominal pain | Kidney problems |
| Constipation | Heart attack |
| Diarrhea | Stroke |
| Headache | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Dizziness | Fluid retention/Edema |
| Rash | High blood pressure |
Oxaprozin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoarthritis | 600-1200 mg | 600-1200 mg once daily | Take with food or after meals to reduce stomach upset. Maximum dose is 1800mg daily. |
| Rheumatoid Arthritis | 600-1200 mg | 600-1200 mg once daily | Take with food or after meals to reduce stomach upset. Maximum dose is 1800mg daily. |
| Juvenile Rheumatoid Arthritis (patients ≥6 years old, weighing 25-50 kg) | 900 mg | 900 mg once daily | Administer as a single dose. Dosage may be adjusted by physician. |
| Juvenile Rheumatoid Arthritis (patients ≥6 years old, weighing >50 kg) | 1200 mg | 1200 mg once daily | Administer as a single dose. Dosage may be adjusted by physician. |
Oxaprozin Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 |
| Without Insurance (U.S.) | $60 – $120 |
| From CPS | $45.35 |
