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General Medication Fact Sheet for Paliperidone
| Field | Information |
|---|---|
| Generic Name | Paliperidone |
| Brand Name Versions | Invega, Invega Sustenna, Invega Trinza |
| Boxed/Label Warning | Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. |
| Purpose | Atypical antipsychotic used to treat schizophrenia and schizoaffective disorder. |
| Mechanism of Action | Antagonizes dopamine D2 and serotonin 5-HT2A receptors in the brain. |
| Dosage Forms | Oral extended-release tablets, injectable suspension |
| Available Strengths | Oral: 1.5 mg, 3 mg, 6 mg, 9 mg; Injectable: Multiple strengths, consult product label. |
| Dosage Frequency | Oral: Once daily; Injectable: Varies depending on formulation (Sustenna: monthly, Trinza: every 3 months). |
| Common Side Effects | Drowsiness, dizziness, weight gain, restlessness, muscle stiffness, increased prolactin levels. |
| Serious Side Effects | Neuroleptic Malignant Syndrome (NMS), tardive dyskinesia, hyperglycemia, hyperlipidemia, orthostatic hypotension, seizures. |
| Drug Interactions | Other CNS depressants (e.g., alcohol, benzodiazepines), antihypertensives, drugs that prolong the QT interval. |
| Important Notes | Monitor for signs of hyperglycemia, hyperlipidemia, and tardive dyskinesia. Avoid alcohol. Use caution when driving or operating machinery. |
| Storage | Store oral tablets at room temperature away from moisture and light. Store injectable suspension as directed on the product label. |
| Missed Dose | Oral: Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. Injectable: Contact your healthcare provider for instructions. |
| Alternatives | Risperidone, Quetiapine, Aripiprazole, Olanzapine |
Paliperidone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Risperidone (Risperdal) | Dopamine and serotonin antagonist | Similar mechanism of action; available in oral and injectable forms. |
| Quetiapine (Seroquel) | Dopamine and serotonin antagonist | Also used for bipolar disorder and depression. |
| Aripiprazole (Abilify) | Dopamine and serotonin partial agonist | May have a different side effect profile compared to paliperidone. |
| Olanzapine (Zyprexa) | Dopamine and serotonin antagonist | Associated with a higher risk of weight gain and metabolic side effects. |
Paliperidone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Neuroleptic Malignant Syndrome (NMS) |
| Dizziness | Tardive dyskinesia |
| Weight gain | Hyperglycemia (high blood sugar) |
| Restlessness | Hyperlipidemia (high cholesterol) |
| Muscle stiffness | Orthostatic hypotension (low blood pressure upon standing) |
| Increased prolactin levels | Seizures |
Paliperidone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia (Oral) | 3 mg once daily | 3-12 mg once daily | Adjust based on individual response and tolerability. |
| Schizoaffective Disorder (Oral) | 6 mg once daily | 3-12 mg once daily | Adjust based on individual response and tolerability. |
| Schizophrenia (Injectable Sustenna) | Initial: 234 mg on day 1, 156 mg on day 8 | Maintenance: 117 mg monthly | Administered intramuscularly by a healthcare professional. |
Paliperidone Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $200 – $400 |
| From CPS | $124.95 |
