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General Medication Fact Sheet for Palladia
| Field | Information |
|---|---|
| Medication Name | Palladia |
| Generic Name | Toceranib Phosphate |
| Purpose | Treatment of mast cell tumors in dogs |
| Mechanism of Action | Inhibits receptor tyrosine kinases (RTKs), disrupting tumor growth and angiogenesis |
| Dosage Forms | Oral tablets |
| Available Strengths | 10 mg, 15 mg, 50 mg |
| Dosage Frequency | Typically administered every other day, or as directed by a veterinarian |
| Common Side Effects | Diarrhea, vomiting, decreased appetite, lethargy, lameness |
| Serious Side Effects | Gastrointestinal ulceration, hemorrhage, proteinuria, hepatotoxicity, hypertension |
| Drug Interactions | NSAIDs (e.g., carprofen), other chemotherapeutic agents; use caution with drugs metabolized by cytochrome P450 enzymes |
| Important Notes | Monitor for signs of gastrointestinal distress and hypertension; regular bloodwork is essential; wear gloves when handling |
| Storage | Store at room temperature away from moisture and light, out of reach of children and pets |
| Missed Dose | Administer as soon as you remember, but do not double the next dose; consult your veterinarian |
| Alternatives | Chemotherapy (e.g., vinblastine), surgery, radiation therapy, corticosteroids (e.g., prednisone) |
Palladia Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Vinblastine | Microtubule inhibitor | Chemotherapeutic agent used for mast cell tumors. |
| Prednisone | Corticosteroid | Used to reduce inflammation and tumor size. |
| Surgery | Physical removal of the tumor | May be curative for localized tumors. |
| Radiation Therapy | Damages DNA of cancer cells | Used to control tumor growth and spread. |
Palladia Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Gastrointestinal ulceration |
| Vomiting | Gastrointestinal hemorrhage |
| Decreased appetite | Proteinuria |
| Lethargy | Hepatotoxicity |
| Lameness | Hypertension |
Palladia Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Mast Cell Tumor | 3.25 mg/kg | 3.25 mg/kg every other day | Administer orally; monitor for side effects; adjust dose as needed by veterinarian |
Palladia Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $400 |
| Without Insurance (U.S.) | $1500 – $1,500 |
| From CPS | $NA |
