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General Medication Fact Sheet for Papaverine Injections
| Field | Information |
|---|---|
| Generic Name | Papaverine |
| Brand Name Versions | Pavabid, Cerespan (Discontinued) |
| Purpose | Vasodilator used to treat erectile dysfunction (ED), vascular spasm, and visceral spasm |
| Mechanism of Action | Relaxes vascular smooth muscle by inhibiting phosphodiesterase, increasing intracellular cAMP levels |
| Dosage Forms | Injectable solution |
| Available Strengths | 30 mg/mL |
| Dosage Frequency | As directed by a healthcare provider, typically injected into the penis for ED or administered intravenously/intramuscularly for other conditions |
| Common Side Effects | Flushing, sweating, headache, dizziness, nausea, mild hypotension |
| Serious Side Effects | Significant hypotension, arrhythmia, priapism (prolonged erection), liver damage, hypersensitivity reactions |
| Drug Interactions | Other vasodilators, antihypertensives, anticoagulants, levodopa |
| Important Notes | Administered by a healthcare professional or as instructed; monitor for signs of hypotension or priapism. Use with caution in patients with glaucoma or coronary insufficiency. |
| Storage | Store at room temperature, protected from light |
| Missed Dose | Since administered by a healthcare professional or on-demand, consult your doctor |
| Alternatives | Alprostadil, Sildenafil (Viagra), Tadalafil (Cialis), Phentolamine, Verapamil |
Papaverine Injections Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Alprostadil (Caverject, Edex) | Prostaglandin E1 analog that relaxes smooth muscle | Injected directly into the penis for ED; can cause penile pain or fibrosis. |
| Sildenafil (Viagra) | PDE5 inhibitor, enhancing nitric oxide effects | Oral medication for ED; requires sexual stimulation to work. |
| Tadalafil (Cialis) | PDE5 inhibitor, longer duration of action than Sildenafil | Oral medication for ED; can be taken daily or on-demand. |
| Phentolamine | Alpha-adrenergic blocker, relaxes smooth muscle | May be used in combination with papaverine for intracavernosal injections. |
| Verapamil | Calcium channel blocker, reduces muscle spasms | May be used in combination with papaverine for intracavernosal injections. |
Papaverine Injections Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Flushing | Significant hypotension |
| Sweating | Arrhythmia |
| Headache | Priapism (prolonged erection) |
| Dizziness | Liver damage |
| Nausea | Hypersensitivity reactions (rash, itching, swelling) |
Papaverine Injections Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Erectile Dysfunction | 2.5 – 30 mg | Individualized based on response | Injected directly into the penis. Titrate to desired effect. Supervised by a physician initially. |
| Vascular Spasm | 30-300mg | 30-300mg every 3 hours | Administered intravenously or intramuscularly. Dosage varies widely. |
| Visceral Spasm | 30-300mg | 30-300mg every 3 hours | Administered intravenously or intramuscularly. Dosage varies widely. |
