Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Paricalcitol (Generic)
| Zemplar Paricalcitol | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Paricalcitol
| Field | Information |
|---|---|
| Generic Name | Paricalcitol |
| Brand Name Versions | Zemplar |
| Purpose | Vitamin D analog used to prevent and treat secondary hyperparathyroidism associated with chronic kidney disease. |
| Mechanism of Action | Selectively activates the vitamin D receptor (VDR) in the parathyroid glands, suppressing parathyroid hormone (PTH) synthesis and secretion. |
| Dosage Forms | Intravenous injection, Oral capsules |
| Available Strengths | Injection: 5 mcg/mL; Capsules: 1 mcg, 2 mcg, 4 mcg |
| Dosage Frequency | Typically three times a week for injection, or daily/three times a week for capsules, as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, constipation, weakness, swelling in the arms or legs. |
| Serious Side Effects | High calcium levels (hypercalcemia), allergic reactions (rash, itching, swelling, difficulty breathing), kidney problems. |
| Drug Interactions | Other vitamin D supplements, calcium supplements, phosphate binders, digoxin, thiazide diuretics. |
| Important Notes | Regular monitoring of calcium and PTH levels is necessary. Follow dietary restrictions as advised by your doctor. |
| Storage | Store capsules at room temperature away from moisture and light. Store injection as directed by the manufacturer. |
| Missed Dose | Take as soon as you remember; if it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Calcitriol, Doxercalciferol |
Paricalcitol Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Calcitriol (Rocaltrol) | Active form of vitamin D; increases calcium absorption from the intestine and releases calcium from bone. | May increase the risk of hypercalcemia compared to paricalcitol. |
| Doxercalciferol (Hectorol) | Vitamin D2 analog that is activated in the liver to form 1alpha,25-dihydroxyergocalciferol. | Another option for treating secondary hyperparathyroidism. |
Paricalcitol Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | High calcium levels (hypercalcemia) |
| Vomiting | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Kidney problems |
| Constipation | Mental/mood changes |
| Weakness | Bone pain |
Paricalcitol Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Secondary Hyperparathyroidism (IV) | 0.04 mcg/kg three times a week | Adjust based on PTH levels (target 150-300 pg/mL) | Administered during dialysis. |
| Secondary Hyperparathyroidism (Oral) | 1 mcg daily or 2 mcg three times a week | Adjust based on PTH levels (target 150-300 pg/mL) | May be taken with or without food. |
Paricalcitol Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $150 |
| From Canada | $50 |
