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General Medication Fact Sheet for Parnate
| Field | Information |
|---|---|
| Medication Name | Parnate |
| Generic Name | Tranylcypromine |
| Boxed/Label Warning | May cause suicidal thoughts or actions in some children and young adults, especially within the first few months of treatment or when the dose is changed. |
| Purpose | Antidepressant used to treat major depressive disorder. |
| Mechanism of Action | Monoamine oxidase inhibitor (MAOI); increases the levels of norepinephrine, serotonin, and dopamine in the brain by inhibiting the enzyme monoamine oxidase. |
| Dosage Forms | Oral tablets |
| Available Strengths | 10 mg |
| Dosage Frequency | Typically two to three times daily, as directed by a healthcare provider. |
| Common Side Effects | Dizziness, headache, insomnia, dry mouth, constipation, nausea, orthostatic hypotension (low blood pressure upon standing). |
| Serious Side Effects | Hypertensive crisis (severe high blood pressure), serotonin syndrome, liver damage, suicidal thoughts or actions, mania. |
| Drug Interactions | Other antidepressants (SSRIs, SNRIs, TCAs), sympathomimetic drugs (e.g., decongestants), certain pain medications (e.g., tramadol), stimulants, some foods high in tyramine (aged cheeses, cured meats, etc.). |
| Important Notes | Requires a strict dietary regimen to avoid foods high in tyramine. Avoid taking with other medications that increase serotonin levels. Monitor blood pressure regularly. Consult a doctor before starting or stopping any medications. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Selegiline (Emsam), Phenelzine (Nardil), Isocarboxazid (Marplan), Amitriptyline, Sertraline (Zoloft) |
Parnate Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Selegiline (Emsam) | Selective MAO-B inhibitor | Available as a transdermal patch; may have fewer dietary restrictions at lower doses. |
| Phenelzine (Nardil) | Non-selective MAOI | Another MAOI with similar considerations regarding diet and drug interactions. |
| Isocarboxazid (Marplan) | Non-selective MAOI | Another MAOI with similar considerations regarding diet and drug interactions. |
| Amitriptyline | Tricyclic antidepressant (TCA); inhibits reuptake of serotonin and norepinephrine. | TCAs have different side effect profiles and drug interactions compared to MAOIs. |
| Sertraline (Zoloft) | Selective serotonin reuptake inhibitor (SSRI); selectively inhibits the reuptake of serotonin. | SSRI’s have different side effect profiles and drug interactions compared to MAOIs. |
Parnate Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | Hypertensive crisis (severe high blood pressure) |
| Headache | Serotonin syndrome |
| Insomnia | Liver damage |
| Dry mouth | Suicidal thoughts or actions |
| Constipation | Mania |
| Nausea | Severe allergic reaction (rash, itching, swelling, difficulty breathing) |
| Orthostatic hypotension (low blood pressure upon standing) |
Parnate Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Major Depressive Disorder | 10 mg twice daily | 30-60 mg daily, divided into multiple doses | Take as directed by your doctor. Follow a tyramine-restricted diet. |
Parnate Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $150 |
| From Canada | $76.18 |
