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General Medication Fact Sheet for Pentoxifylline
| Field | Information |
|---|---|
| Generic Name | Pentoxifylline |
| Brand Name Versions | Trental |
| Purpose | Used to improve blood flow in patients with peripheral artery disease |
| Mechanism of Action | Improves blood flow by increasing red blood cell flexibility and reducing blood viscosity |
| Dosage Forms | Extended-release oral tablets |
| Available Strengths | 400 mg |
| Dosage Frequency | Typically three times daily, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, dizziness, headache |
| Serious Side Effects | Chest pain, irregular heartbeat, shortness of breath, severe allergic reactions |
| Drug Interactions | Anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin, Clopidogrel), theophylline, ciprofloxacin |
| Important Notes | Take with food to minimize gastrointestinal upset; avoid alcohol; monitor for signs of bleeding |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Cilostazol, Aspirin, Clopidogrel |
Pentoxifylline Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Cilostazol (Pletal) | Phosphodiesterase III inhibitor; vasodilator and antiplatelet agent | Improves blood flow and reduces leg pain in peripheral artery disease. |
| Aspirin | Antiplatelet agent; inhibits thromboxane A2 production | Used to prevent blood clots and improve blood flow. |
| Clopidogrel (Plavix) | Antiplatelet agent; inhibits platelet aggregation | Used to prevent blood clots and reduce the risk of stroke and heart attack. |
Pentoxifylline Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Chest pain |
| Vomiting | Irregular heartbeat |
| Dizziness | Shortness of breath |
| Headache | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Indigestion | Bleeding or bruising easily |
Pentoxifylline Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Peripheral Artery Disease | 400 mg | 400 mg three times daily | Take with food to minimize gastrointestinal upset. |
