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General Medication Fact Sheet for Perphenazine
| Field | Information |
|---|---|
| Generic Name | Perphenazine |
| Brand Name Versions | Trilafon |
| Boxed/Label Warning | Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Perphenazine is not approved for the treatment of dementia-related psychosis. |
| Purpose | Antipsychotic medication used to treat schizophrenia and other psychotic disorders; also used to control severe nausea and vomiting. |
| Mechanism of Action | Blocks dopamine receptors in the brain, reducing psychotic symptoms. Also has antiemetic effects by blocking dopamine receptors in the chemoreceptor trigger zone. |
| Dosage Forms | Oral tablets, Oral concentrate |
| Available Strengths | 2 mg, 4 mg, 8 mg, 16 mg |
| Dosage Frequency | Typically two to four times daily, or as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dizziness, dry mouth, blurred vision, constipation, muscle stiffness, tremors. |
| Serious Side Effects | Tardive dyskinesia (involuntary movements), neuroleptic malignant syndrome (high fever, muscle rigidity, altered mental status), seizures, irregular heartbeat, severe allergic reactions. |
| Drug Interactions | Other antipsychotics, antidepressants, antihistamines, sedatives, alcohol, anticholinergics, blood pressure medications. |
| Important Notes | May cause drowsiness; use caution when driving or operating machinery. Avoid alcohol. Consult a doctor if you experience uncontrolled movements, fever, or muscle stiffness. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Haloperidol, Risperidone, Olanzapine, Quetiapine |
Perphenazine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Haloperidol (Haldol) | Dopamine receptor antagonist | A typical antipsychotic with a high risk of extrapyramidal side effects. |
| Risperidone (Risperdal) | Dopamine and serotonin receptor antagonist | An atypical antipsychotic with fewer extrapyramidal side effects than typical antipsychotics. |
| Olanzapine (Zyprexa) | Dopamine and serotonin receptor antagonist | An atypical antipsychotic associated with weight gain and metabolic side effects. |
| Quetiapine (Seroquel) | Dopamine and serotonin receptor antagonist | An atypical antipsychotic often used for both psychosis and mood disorders. |
Perphenazine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Tardive dyskinesia (involuntary movements) |
| Dizziness | Neuroleptic malignant syndrome (NMS) |
| Dry mouth | Seizures |
| Blurred vision | Irregular heartbeat |
| Constipation | Severe allergic reactions |
| Muscle stiffness | Agranulocytosis (low white blood cell count) |
| Tremors | Increased risk of death in elderly patients with dementia-related psychosis |
Perphenazine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia | 4-8 mg per day | 8-16 mg per day, divided into multiple doses | Adjust dose based on response and tolerance. |
| Nausea and Vomiting | 8-16 mg per day | 8-16 mg per day, divided into multiple doses | Use the lowest effective dose; short term use only. |
Perphenazine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $35 |
| From CPS | $21.95 |
