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General Medication Fact Sheet for Pifeltro
| Field | Information |
|---|---|
| Medication Name | Pifeltro |
| Generic Name | Doravirine |
| Purpose | Antiretroviral medication used to treat HIV-1 infection |
| Mechanism of Action | Non-nucleoside reverse transcriptase inhibitor (NNRTI); inhibits HIV-1 reverse transcriptase |
| Dosage Forms | Oral tablets |
| Available Strengths | 100 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Nausea, headache, fatigue, diarrhea, abnormal dreams |
| Serious Side Effects | Severe rash, liver problems, depression or mood changes |
| Drug Interactions | Certain anticonvulsants (e.g., carbamazepine, phenytoin), rifamycins (e.g., rifampin), St. John’s Wort |
| Important Notes | Must be taken with food; consult a doctor before taking other medications or supplements |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember unless it is close to your next dose. Do not double the dose. |
| Alternatives | Sustiva (efavirenz), Edurant (rilpivirine), Tivicay (dolutegravir), Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) |
Pifeltro Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sustiva (efavirenz) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) | Older NNRTI, associated with more neuropsychiatric side effects. |
| Edurant (rilpivirine) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) | Must be taken with a meal; not suitable for patients with high viral load. |
| Tivicay (dolutegravir) | Integrase strand transfer inhibitor (INSTI) | Generally well-tolerated and effective. |
| Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) | INSTI-based single-tablet regimen | Highly effective and convenient, but may not be suitable for all patients. |
Pifeltro Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe rash |
| Headache | Liver problems |
| Fatigue | Depression or mood changes |
| Diarrhea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Abnormal dreams | Suicidal thoughts |
Pifeltro Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV-1 Infection | 100 mg | 100 mg once daily | Take with food at approximately the same time each day. |
Pifeltro Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $1,800 – $2,300 |
| From CPS | $786.70 |
