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Pimozide
| Orap Pimozide | ||||||
Shipped from United Kingdom | ||||||
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General Medication Fact Sheet for Pimozide
| Field | Information |
|---|---|
| Medication Name | Pimozide |
| Generic Name | Pimozide |
| Boxed/Label Warning | Pimozide is contraindicated in patients with congenital long QT syndrome or a history of cardiac arrhythmias. ECG monitoring is recommended. |
| Purpose | Antipsychotic medication used to treat Tourette’s syndrome and, in some cases, delusional parasitosis. |
| Mechanism of Action | Blocks dopamine D2 receptors in the brain, reducing dopaminergic neurotransmission. Also blocks serotonin receptors. |
| Dosage Forms | Oral tablets |
| Available Strengths | 1 mg, 2 mg, 4 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dry mouth, muscle stiffness, blurred vision, constipation. |
| Serious Side Effects | QT prolongation, cardiac arrhythmias, neuroleptic malignant syndrome (NMS), tardive dyskinesia, seizures. |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, itraconazole), antiarrhythmics (e.g., quinidine, amiodarone), other antipsychotics, macrolide antibiotics (e.g., erythromycin, clarithromycin). |
| Important Notes | Requires ECG monitoring before and during treatment. Avoid grapefruit juice. Use caution when driving or operating machinery. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Haloperidol, Risperidone, Aripiprazole, Fluphenazine |
Pimozide Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Haloperidol (Haldol) | Dopamine D2 receptor antagonist | Typical antipsychotic; may have a higher risk of extrapyramidal side effects. |
| Risperidone (Risperdal) | Dopamine D2 and serotonin 5-HT2A receptor antagonist | Atypical antipsychotic; generally has a lower risk of extrapyramidal side effects compared to Haloperidol. |
| Aripiprazole (Abilify) | Partial dopamine D2 and serotonin 5-HT1A receptor agonist; serotonin 5-HT2A receptor antagonist | Atypical antipsychotic with a unique mechanism of action; may have a lower risk of weight gain. |
| Fluphenazine (Prolixin) | Dopamine D2 receptor antagonist | Typical antipsychotic, available in long-acting injectable form. |
Pimozide Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | QT prolongation |
| Dry mouth | Cardiac arrhythmias (Torsades de Pointes) |
| Muscle stiffness | Neuroleptic Malignant Syndrome (NMS) |
| Blurred vision | Tardive Dyskinesia |
| Constipation | Seizures |
| Weight gain | Extrapyramidal symptoms (EPS) |
Pimozide Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Tourette’s Syndrome | 1-2 mg daily | Adjusted based on response and tolerance, typically 4-10 mg daily | Administer once daily. Monitor ECG regularly. |
| Delusional Parasitosis | 1-2 mg daily | Adjusted based on response and tolerance, typically 1-6 mg daily | Administer once daily. Use with caution; not FDA-approved for this indication. |
Pimozide Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $20 – $50 |
| From Canada | $48.95 |
