Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Piqray
| Field | Information |
|---|---|
| Medication Name | Piqray |
| Generic Name | Alpelisib |
| Boxed/Label Warning | Severe hypersensitivity reactions, including anaphylaxis, and severe cutaneous adverse reactions, including Stevens-Johnson syndrome (SJS) and erythema multiforme (EM) have been reported. Discontinue Piqray immediately for any sign of severe hypersensitivity or severe cutaneous adverse reactions. |
| Purpose | Used in combination with fulvestrant to treat postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer after progression following endocrine therapy. |
| Mechanism of Action | Inhibits phosphatidylinositol-3-kinase (PI3K), specifically the PI3Kα isoform. PIK3CA mutations can lead to activation of the PI3K pathway, promoting cell growth and survival. |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg, 150 mg |
| Dosage Frequency | Once daily, taken with fulvestrant. |
| Common Side Effects | Hyperglycemia, diarrhea, nausea, decreased appetite, rash, fatigue, vomiting, stomatitis, weight loss, hypocalcemia |
| Serious Side Effects | Severe allergic reactions, severe skin reactions, hyperglycemia, diarrhea, pneumonitis, liver problems |
| Drug Interactions | Strong CYP3A4 inhibitors and inducers may alter alpelisib concentrations. Avoid concomitant use if possible. |
| Important Notes | Monitor blood glucose levels regularly due to the risk of hyperglycemia. Patients should be pre-treated with antiemetics and antidiarrheals. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed, it should not be taken later that day. The next dose should be taken at the usual time the next day. |
| Alternatives | Everolimus, Palbociclib, Ribociclib, Letrozole, Anastrozole |
Piqray Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Everolimus (Afinitor) | mTOR inhibitor | Used in HR-positive, HER2-negative breast cancer; often combined with exemestane. |
| Palbociclib (Ibrance) | CDK4/6 inhibitor | Used in HR-positive, HER2-negative breast cancer; often combined with aromatase inhibitors or fulvestrant. |
| Ribociclib (Kisqali) | CDK4/6 inhibitor | Used in HR-positive, HER2-negative breast cancer; often combined with aromatase inhibitors or fulvestrant. |
| Letrozole (Femara) | Aromatase inhibitor | First-line endocrine therapy for postmenopausal women with HR-positive breast cancer. |
| Anastrozole (Arimidex) | Aromatase inhibitor | Alternative first-line endocrine therapy for postmenopausal women with HR-positive breast cancer. |
Piqray Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hyperglycemia | Severe allergic reactions (anaphylaxis) |
| Diarrhea | Severe skin reactions (Stevens-Johnson syndrome, erythema multiforme) |
| Nausea | Pneumonitis |
| Decreased appetite | Liver problems (hepatotoxicity) |
| Rash | Hyperglycemia leading to diabetic ketoacidosis or hyperosmolar hyperglycemic state |
Piqray Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HR-positive, HER2-negative, PIK3CA-mutated Advanced Breast Cancer | 300 mg once daily | 300 mg once daily | Taken with fulvestrant 500 mg intramuscularly on days 1, 15, and 29, then monthly. Take Piqray immediately after food. |
Piqray Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $22,000 |
| From CPS | $9,340 |
Why Americans Buy Piqray from Canada Pharmacy Store?
Why Americans Buy Piqray from Canada Pharmacy Store?
Americans have trouble affording Piqray due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Piqray prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Piqray prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Piqray Online
How to Order Piqray Online
Step 1
Select Your Prescribed Piqray Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Piqray Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Piqray Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Piqray you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Piqray at a lower price, simply place your order above or give us a call at 1-888-903-2240
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