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General Medication Fact Sheet for Plegridy
| Field | Information |
|---|---|
| Medication Name | Plegridy |
| Generic Name | Peginterferon beta-1a |
| Purpose | Used to treat relapsing forms of multiple sclerosis (MS) |
| Mechanism of Action | Modulates the inflammatory response in MS by reducing the activation of immune cells and reducing their migration to the brain and spinal cord. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 125 mcg/0.5 mL |
| Dosage Frequency | Every 14 days (subcutaneously) |
| Common Side Effects | Flu-like symptoms (fever, chills, muscle aches), injection site reactions (redness, swelling, pain), headache, fatigue |
| Serious Side Effects | Liver problems, depression or suicidal thoughts, seizures, allergic reactions, heart problems |
| Drug Interactions | Other immunomodulators or immunosuppressants, medications that affect liver function, live vaccines. |
| Important Notes | Monitor for depression and suicidal thoughts. Report any signs of liver problems to your doctor. Avoid live vaccines while on Plegridy. |
| Storage | Store in the refrigerator (2-8°C or 36-46°F). Do not freeze. Protect from light. |
| Missed Dose | If you miss a dose, inject it as soon as you remember, unless it’s almost time for your next dose. Contact your doctor for guidance. |
| Alternatives | Avonex (interferon beta-1a), Rebif (interferon beta-1a), Copaxone (glatiramer acetate), Gilenya (fingolimod) |
Plegridy Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Avonex (interferon beta-1a) | Modulates immune response. | Another interferon beta product, administered intramuscularly. |
| Rebif (interferon beta-1a) | Modulates immune response. | Another interferon beta product, administered subcutaneously three times per week. |
| Copaxone (glatiramer acetate) | Alters immune processes thought to be responsible for MS. | A non-interferon option, administered subcutaneously. |
| Gilenya (fingolimod) | Sphingosine 1-phosphate receptor modulator. | An oral medication that traps lymphocytes in lymph nodes, reducing inflammation in the brain and spinal cord. |
Plegridy Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Flu-like symptoms (fever, chills, muscle aches) | Liver problems (jaundice, dark urine) |
| Injection site reactions (redness, swelling, pain) | Depression or suicidal thoughts |
| Headache | Seizures |
| Fatigue | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Nausea | Heart problems (chest pain, irregular heartbeat) |
Plegridy Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Relapsing Multiple Sclerosis | 63 mcg subcutaneously on day 1, then 94 mcg subcutaneously on day 15 | 125 mcg subcutaneously every 14 days starting on day 29 | Inject subcutaneously, rotating injection sites. Refer to the manufacturer’s instructions for administration details. |
Plegridy Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $70 |
| Without Insurance (U.S.) | $8,500 |
| From CPS | $2,960 |
