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Pletal (Cilostazol)
| Cilostazol (Generic) Cilostazol | ||||||
Shipped from United Kingdom | ||||||
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| Cilostazol (Generic) Cilostazol | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Pletal
| Field | Information |
|---|---|
| Medication Name | Pletal |
| Generic Name | Cilostazol |
| Boxed/Label Warning | Cilostazol and other phosphodiesterase III inhibitors are contraindicated in patients with heart failure of any severity. Cilostazol has been shown to reduce survival compared to placebo in patients with New York Heart Association (NYHA) class III-IV heart failure. |
| Purpose | Used to reduce the symptoms of intermittent claudication (leg pain with exercise) |
| Mechanism of Action | A phosphodiesterase III inhibitor that suppresses platelet aggregation and is a direct arterial vasodilator. |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg, 100 mg |
| Dosage Frequency | Typically twice daily, at least half an hour before or two hours after breakfast and dinner. |
| Common Side Effects | Headache, diarrhea, abnormal stools, palpitations, dizziness, peripheral edema |
| Serious Side Effects | Severe headache, chest pain, irregular heartbeat, fainting, signs of bleeding (easy bruising, prolonged bleeding from cuts) |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, diltiazem), CYP2C19 inhibitors (e.g., omeprazole), aspirin, warfarin, clopidogrel |
| Important Notes | Take on an empty stomach; avoid grapefruit juice; inform your doctor of any heart conditions or bleeding disorders. Do not use if you have heart failure. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it’s close to the time for your next dose. Do not double the dose. |
| Alternatives | Pentoxifylline (Trental), Aspirin, Clopidogrel (Plavix), Exercise therapy |
Pletal Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Pentoxifylline (Trental) | Improves blood flow by increasing red blood cell flexibility and decreasing blood viscosity. | May take several weeks to see improvement; less effective than cilostazol for some patients. |
| Clopidogrel (Plavix) | Inhibits platelet aggregation by blocking ADP binding to its platelet receptor. | Another antiplatelet medication, often used in patients with peripheral artery disease. |
| Exercise therapy | Improves circulation and reduces symptoms of intermittent claudication. | A non-pharmacological approach that can be highly effective; often recommended as a first-line treatment. |
Pletal Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Severe headache |
| Diarrhea | Chest pain |
| Abnormal stools | Irregular heartbeat |
| Palpitations | Fainting |
| Dizziness | Signs of bleeding (easy bruising, prolonged bleeding from cuts) |
| Peripheral edema | Heart attack |
| Rapid heart rate | Stroke |
Pletal Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Intermittent Claudication | 50 mg twice daily or 100 mg twice daily | 50 mg twice daily or 100 mg twice daily (depending on tolerance and response) | Take at least 30 minutes before or 2 hours after breakfast and dinner. |
Pletal Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $40 |
| Without Insurance (U.S.) | $600 |
| From CPS | $70 |
