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General Medication Fact Sheet for Podofilm
| Field | Information |
|---|---|
| Medication Name | Podofilm |
| Generic Name | Podophyllin Resin |
| Boxed/Label Warning | Podophyllin Resin is highly toxic and should only be applied by a healthcare provider. It is contraindicated in pregnancy. |
| Purpose | Topical treatment of genital and perianal warts (condylomata acuminata) |
| Mechanism of Action | Inhibits cell division by binding to tubulin, arresting mitosis in metaphase, and causing wart tissue necrosis. |
| Dosage Forms | Topical solution |
| Available Strengths | 25% podophyllin resin in tincture |
| Dosage Frequency | Typically applied once weekly, or as directed by a healthcare provider, for a maximum of 4-6 applications. |
| Common Side Effects | Local irritation, burning, itching, pain, redness, and swelling at the application site. |
| Serious Side Effects | Severe local irritation, ulceration, systemic absorption leading to neurological effects, bone marrow suppression. |
| Drug Interactions | Avoid concurrent use with other topical agents on the treated area. |
| Important Notes | Strictly for external use only. Avoid contact with eyes, mucous membranes, and normal skin. Wash off thoroughly after the prescribed duration. Not for use during pregnancy. |
| Storage | Store in a tightly closed container at room temperature, away from heat and open flame. |
| Missed Dose | Consult your healthcare provider for instructions if a scheduled application is missed. Do not apply extra solution to make up for a missed dose. |
| Alternatives | Imiquimod (Aldara, Zyclara), Podofilox (Condylox), Cryotherapy, Surgical Excision |
Podofilm Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Imiquimod (Aldara, Zyclara) | Immune response modifier | Stimulates the immune system to fight the virus causing warts. Applied topically. |
| Podofilox (Condylox) | Inhibits cell division | Similar mechanism of action to podophyllin resin, but formulated for patient self-application. |
| Cryotherapy | Freezing the wart tissue | Involves applying liquid nitrogen to freeze and destroy the wart. Performed in a medical setting. |
| Surgical Excision | Physical removal of the wart | Surgical removal of the wart tissue, usually reserved for larger or resistant warts. |
Podofilm Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Local irritation | Severe local irritation |
| Burning sensation | Ulceration |
| Itching | Systemic absorption |
| Pain | Neurological effects (rare) |
| Redness | Bone marrow suppression (rare) |
Podofilm Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Genital/Perianal Warts | Apply a thin layer | N/A (Single application per week) | Apply only to warts, avoid surrounding skin. Wash off after 1-4 hours as directed by your doctor. Applied by a healthcare professional. |
