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General Medication Fact Sheet for Posanol Oral Suspension
| Field | Information |
|---|---|
| Medication Name | Posanol Oral Suspension |
| Generic Name | Posaconazole |
| Boxed/Label Warning | Correct administration of posaconazole oral suspension is essential to ensure appropriate plasma posaconazole concentrations. It cannot be directly substituted with other posaconazole products (tablets or IV). |
| Purpose | Antifungal medication used to prevent and treat fungal infections. |
| Mechanism of Action | Inhibits the enzyme lanosterol 14α-demethylase, a cytochrome P450 enzyme essential for ergosterol synthesis. Ergosterol is a crucial component of fungal cell membranes. |
| Dosage Forms | Oral Suspension |
| Available Strengths | 40 mg/mL |
| Dosage Frequency | Typically two or three times daily, depending on the condition being treated, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, headache, fatigue. |
| Serious Side Effects | Liver problems (e.g., elevated liver enzymes, jaundice), QT prolongation, allergic reactions (rash, itching, swelling, difficulty breathing), adrenal insufficiency. |
| Drug Interactions | Many drugs, including certain immunosuppressants (e.g., cyclosporine, tacrolimus), HMG-CoA reductase inhibitors (statins), benzodiazepines, and others metabolized by CYP3A4. Consult a healthcare provider or pharmacist. |
| Important Notes | Take with a full meal to improve absorption. Monitor liver function regularly. Do not use with certain medications. Consult a healthcare provider. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Voriconazole, Fluconazole, Itraconazole, Amphotericin B |
Posanol Oral Suspension Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Voriconazole (Vfend) | Inhibits fungal CYP450 enzymes involved in ergosterol synthesis. | Broad-spectrum antifungal, often used for invasive aspergillosis. |
| Fluconazole (Diflucan) | Inhibits fungal CYP450 enzymes involved in ergosterol synthesis. | Used for various fungal infections, including candidiasis. |
| Itraconazole (Sporanox) | Inhibits fungal CYP450 enzymes involved in ergosterol synthesis. | Used for various fungal infections, including aspergillosis and histoplasmosis. |
| Amphotericin B | Binds to ergosterol in the fungal cell membrane, causing cell death. | Broad-spectrum antifungal, often used for severe fungal infections. Available in various formulations (e.g., liposomal). |
Posanol Oral Suspension Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Liver problems (e.g., elevated liver enzymes, jaundice) |
| Vomiting | QT prolongation |
| Diarrhea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Abdominal pain | Adrenal insufficiency |
| Headache | Severe skin reactions (e.g., Stevens-Johnson syndrome) |
| Fatigue | Electrolyte imbalances (e.g., low potassium) |
Posanol Oral Suspension Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Prophylaxis of Invasive Fungal Infections in High-Risk Patients | 200 mg (5 mL) | 200 mg (5 mL) three times daily | Administer with a full meal to improve absorption. |
| Treatment of Oral Candidiasis | 100 mg (2.5 mL) | 100 mg (2.5 mL) twice daily on the first day, then 100 mg (2.5 mL) once daily for 13 days | Administer without food. |
| Treatment of Invasive Aspergillosis | 200 mg (5 mL) | 200 mg (5 mL) four times daily | Administer with a full meal to improve absorption. |
Posanol Oral Suspension Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $70 |
| Without Insurance (U.S.) | $1,450 |
| From CPS | $1299 |
