Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
General Medication Fact Sheet for Prevymis
| Field | Information |
|---|---|
| Medication Name | Prevymis |
| Generic Name | Leflunomide |
| Boxed/Label Warning | May cause fetal harm. Females of reproductive potential should use effective contraception during treatment and for up to 2 years after stopping treatment. May also cause liver problems. |
| Purpose | Antiviral medication used to prevent cytomegalovirus (CMV) infection in adult kidney transplant recipients at high risk. |
| Mechanism of Action | Inhibits viral DNA terminase complex, preventing viral DNA cleavage and packaging, thus inhibiting CMV replication. |
| Dosage Forms | Oral tablets |
| Available Strengths | 40 mg, 80 mg |
| Dosage Frequency | Once daily, starting on the day of transplantation and continuing through 100 days post-transplant. |
| Common Side Effects | Nausea, diarrhea, vomiting, abdominal pain, edema, fatigue, headache, cough. |
| Serious Side Effects | Bone marrow suppression, hepatotoxicity, hypersensitivity reactions, graft rejection, CMV disease. |
| Drug Interactions | Cyclosporine, tacrolimus, rifampin, certain anticonvulsants (e.g., phenytoin), strong CYP3A4 inducers. |
| Important Notes | Administer with or without food. Monitor liver function tests and complete blood counts regularly. Use effective contraception during treatment and for 3 months after stopping. Report any signs of infection or bleeding immediately to your healthcare provider. |
| Storage | Store at room temperature between 68°F to 77°F (20°C to 25°C), away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. |
| Alternatives | Valganciclovir (Valcyte), Ganciclovir (Cytovene), Foscarnet (Foscavir) |
Prevymis Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Valganciclovir (Valcyte) | Inhibits viral DNA synthesis by competitive inhibition of viral DNA polymerase. | Prodrug of Ganciclovir; commonly used for CMV prophylaxis and treatment. |
| Ganciclovir (Cytovene) | Inhibits viral DNA synthesis by competitive inhibition of viral DNA polymerase. | Used for CMV prophylaxis and treatment; available in intravenous and oral formulations. |
| Foscarnet (Foscavir) | Inhibits viral DNA polymerase and reverse transcriptase by binding to the pyrophosphate-binding site. | Used for CMV infections resistant to Ganciclovir; requires intravenous administration. |
Prevymis Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Bone marrow suppression (anemia, leukopenia, thrombocytopenia) |
| Diarrhea | Hepatotoxicity (liver damage) |
| Vomiting | Hypersensitivity reactions (rash, itching, swelling, difficulty breathing) |
| Abdominal pain | Graft rejection |
| Edema | CMV disease |
| Fatigue | Renal impairment |
Prevymis Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| CMV Prophylaxis in Kidney Transplant Recipients | 40 mg | 40 mg once daily | Start on the day of transplantation and continue through 100 days post-transplant. Administer with or without food. |
Prevymis Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $300 |
| Without Insurance (U.S.) | $22,500 |
| From CPS | $10,528 |
