Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
General Medication Fact Sheet for Primaxin Injections
| Field | Information |
|---|---|
| Medication Name | Primaxin Injections |
| Generic Name | Imipenem and Cilastatin |
| Boxed/Label Warning | Serious hypersensitivity (anaphylactic) reactions and central nervous system (CNS) adverse reactions, including seizures, have been reported. |
| Purpose | Broad-spectrum antibiotic used to treat severe bacterial infections. |
| Mechanism of Action | Imipenem inhibits bacterial cell wall synthesis. Cilastatin prevents the breakdown of imipenem in the kidneys. |
| Dosage Forms | Intravenous injection |
| Available Strengths | 250 mg / 250 mg, 500 mg / 500 mg |
| Dosage Frequency | Every 6-8 hours, as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, injection site reactions, fever. |
| Serious Side Effects | Seizures, allergic reactions (rash, itching, swelling, difficulty breathing), Clostridium difficile-associated diarrhea (CDAD). |
| Drug Interactions | Valproic acid, ganciclovir, probenecid. |
| Important Notes | Administered by healthcare professionals only. Monitor for signs of allergic reactions. Use with caution in patients with a history of seizures or kidney problems. |
| Storage | Store vials according to manufacturer’s instructions, typically refrigerated prior to reconstitution. |
| Missed Dose | This medication is administered by a healthcare professional in a clinical setting, so a missed dose is unlikely. |
| Alternatives | Meropenem, Doripenem, Ertapenem, Piperacillin/Tazobactam |
Primaxin Injections Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Meropenem | Inhibits bacterial cell wall synthesis. | Another broad-spectrum carbapenem antibiotic. |
| Doripenem | Inhibits bacterial cell wall synthesis. | Broad-spectrum carbapenem antibiotic, often used for complicated infections. |
| Ertapenem | Inhibits bacterial cell wall synthesis. | Carbapenem antibiotic with a narrower spectrum than imipenem or Meropenem. |
| Piperacillin/Tazobactam | Piperacillin inhibits bacterial cell wall synthesis; tazobactam inhibits beta-lactamase enzymes. | A penicillin-based antibiotic combined with a beta-lactamase inhibitor. |
Primaxin Injections Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Seizures |
| Vomiting | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Clostridium difficile-associated diarrhea (CDAD) |
| Injection site reactions (pain, redness, swelling) | Kidney problems |
| Fever | Central nervous system (CNS) effects (confusion, tremors) |
Primaxin Injections Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Severe Bacterial Infections (e.g., pneumonia, sepsis) | 250-500 mg | 250-500 mg every 6-8 hours | Dose and frequency depend on the type and severity of infection, kidney function, and other factors. Administered intravenously by a healthcare professional. |
| Urinary Tract Infections (UTIs) | 250 mg | 250 mg every 6 hours | Dosage is adjusted based on the severity of the infection. Administered intravenously by a healthcare professional. |
| Intra-abdominal Infections | 500 mg | 500 mg every 6-8 hours | Dosage is adjusted based on the severity of the infection. Administered intravenously by a healthcare professional. |
