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General Medication Fact Sheet for Prochlorperazine
AlternativesOndansetron, Metoclopramide, Promethazine, Haloperidol, Aripiprazole.
| Field | Information |
|---|---|
| Generic Name | Prochlorperazine |
| Brand Name Versions | Compro, Compazine (Discontinued in the US) |
| Boxed/Label Warning | Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Prochlorperazine is not approved for the treatment of dementia-related psychosis. |
| Purpose | Treats nausea, vomiting, anxiety, and schizophrenia. |
| Mechanism of Action | Blocks dopamine receptors in the brain, which helps reduce nausea, vomiting, and psychotic symptoms. |
| Dosage Forms | Oral tablets, suppositories, injection |
| Available Strengths | Tablets: 5 mg, 10 mg; Suppositories: 2.5 mg, 5 mg, 10 mg; Injection: 5 mg/mL |
| Dosage Frequency | Varies depending on the condition being treated; typically 3-4 times daily for tablets, every 6-8 hours for suppositories, or as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, dizziness, blurred vision, dry mouth, constipation. |
| Serious Side Effects | Tardive dyskinesia, neuroleptic malignant syndrome (NMS), extrapyramidal symptoms (EPS), seizures, low blood pressure. |
| Drug Interactions | Alcohol, CNS depressants, anticholinergic drugs, blood pressure medications, lithium. |
| Important Notes | May cause drowsiness; avoid driving or operating heavy machinery. Inform your doctor if you have a history of seizures, heart problems, or liver disease. Not recommended for use in children under 2 years old. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
Prochlorperazine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ondansetron (Zofran) | Serotonin 5-HT3 receptor antagonist | Primarily used for nausea and vomiting, especially after chemotherapy or surgery. |
| Metoclopramide (Reglan) | Dopamine antagonist and prokinetic agent | Used for nausea, vomiting, and gastroparesis. |
| Promethazine (Phenergan) | Histamine H1 receptor antagonist | Used for nausea, vomiting, and allergic reactions. |
| Haloperidol (Haldol) | Dopamine antagonist | Antipsychotic medication, can also be used for severe nausea and vomiting. |
| Aripiprazole (Abilify) | Atypical antipsychotic; partial dopamine agonist | Used to treat schizophrenia and bipolar disorder. |
Prochlorperazine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Tardive dyskinesia (involuntary movements) |
| Dizziness | Neuroleptic Malignant Syndrome (NMS) |
| Blurred vision | Extrapyramidal symptoms (EPS) |
| Dry mouth | Seizures |
| Constipation | Low blood pressure |
| Restlessness | Irregular Heartbeat |
Prochlorperazine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Nausea and Vomiting | 5-10 mg orally | 5-10 mg orally 3-4 times daily | Take as needed. |
| Anxiety | 5 mg orally | 5-10 mg orally 3-4 times daily | Adjust dose based on response. |
| Schizophrenia | 5-10 mg orally | 10-20 mg orally 3-4 times daily | Adjust dose based on response; may require higher doses for acute episodes. |
